MiRNAs regulate stem cell self-renewal and differentiation

Zuoren Yu; Yuan Li; Huimin Fan; Zhongmin Liu; Richard G. Pestell

doi:10.3389/fgene.2012.00191

MiRNAs regulate stem cell self-renewal and differentiation

Zuoren Yu, Yuan Li, Huimin Fan, Zhongmin Liu, Richard G. Pestell

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed.

Original language	English
Article number	Article 191
Journal	Frontiers in Genetics
Volume	3
Issue number	SEP
DOIs	https://doi.org/10.3389/fgene.2012.00191
Publication status	Published - 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fgene.2012.00191Licence: CC BY

Cite this

@article{a41b5441b095498f8f4c72c68bb830bc,

title = "MiRNAs regulate stem cell self-renewal and differentiation",

abstract = "Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed.",

keywords = "Epigenetic modification, MicroRNA, Self-renewal, Stem cell",

author = "Zuoren Yu and Yuan Li and Huimin Fan and Zhongmin Liu and Pestell, {Richard G.}",

year = "2012",

doi = "10.3389/fgene.2012.00191",

language = "English",

volume = "3",

journal = "Frontiers in Genetics",

issn = "1664-8021",

publisher = "Frontiers Media SA",

number = "SEP",

}

TY - JOUR

T1 - MiRNAs regulate stem cell self-renewal and differentiation

AU - Yu, Zuoren

AU - Li, Yuan

AU - Fan, Huimin

AU - Liu, Zhongmin

AU - Pestell, Richard G.

PY - 2012

Y1 - 2012

N2 - Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed.

AB - Stem cells undergo symmetric and asymmetric divisions to generate differentiated cells and more stem cells. The balance between self-renewal and differentiation of stem cells is controlled by transcription factors, epigenetic regulatory networks, and microRNAs (miRNAs). Herein the miRNA involvement in the regulation of stem cell self-renewal and differentiation is summarized. miRNA contribution to malignancy through regulating cancer stem cells is described. In addition, the reciprocal associations between miRNAs and epigenetic modifications in control of stem cell fate are discussed.

KW - Epigenetic modification

KW - MicroRNA

KW - Self-renewal

KW - Stem cell

UR - http://www.scopus.com/inward/record.url?scp=84874642698&partnerID=8YFLogxK

U2 - 10.3389/fgene.2012.00191

DO - 10.3389/fgene.2012.00191

M3 - Article

AN - SCOPUS:84874642698

SN - 1664-8021

VL - 3

JO - Frontiers in Genetics

JF - Frontiers in Genetics

IS - SEP

M1 - Article 191

ER -

MiRNAs regulate stem cell self-renewal and differentiation

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this