MiR-214 is an important regulator of the musculoskeletal metabolism and disease

Youqiang Sun; Vincent Kuek; Yuhao Liu; Jennifer Tickner; Yu Yuan; Leilei Chen; Zhikui Zeng; Min Shao; Wei He; Jiake Xu

doi:10.1002/jcp.26856

MiR-214 is an important regulator of the musculoskeletal metabolism and disease

Youqiang Sun, Vincent Kuek, Yuhao Liu, Jennifer Tickner, Yu Yuan, Leilei Chen, Zhikui Zeng, Min Shao, Wei He, Jiake Xu

Research output: Contribution to journal › Review article › peer-review

58 Citations (Scopus)

Abstract

MiR-214 belongs to a family of microRNA (small, highly conserved noncoding RNA molecules) precursors that play a pivotal role in biological functions, such as cellular function, tissue development, tissue homeostasis, and pathogenesis of diseases. Recently, miR-214 emerged as a critical regulator of musculoskeletal metabolism. Specifically, miR-214 can mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration, and differentiation. MiR-214 also modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes; promotes osteoclast activity by targeting phosphatase and tensin homolog (Pten); and mediates osteoclast-osteoblast intercellular crosstalk via an exosomal miRNA paracrine mechanism. Importantly, dysregulation in miR-214 expression is associated with pathological bone conditions such as osteoporosis, osteosarcoma, multiple myeloma, and osteolytic bone metastasis of breast cancer. This review discusses the cellular targets of miR-214 in bone, the molecular mechanisms governing the activities of miR-214 in the musculoskeletal system, and the putative role of miR-214 in skeletal diseases. Understanding the biology of miR-214 could potentially lead to the development of miR-214 as a possible biomarker and a therapeutic target for musculoskeletal diseases.

Highlights

MiR-214 is an important regulator of the musculoskeletal system and is involved in muscle development, bone homeostasis and bone-related disorders.

MiR-214 is able to mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration and differentiation.

MiR-214 modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes.

MiR-214 promotes osteoclast activity by targeting specific genes and mediates osteoblast-osteoclast intercellular crosstalk via an exosomal miRNA paracrine mechanism.

Dysregulation in miR-214 expression has been associated with bone diseases such as osteoporosis, osteosarcoma and multiple myeloma.

Osteoclastic miR-214 is involved in regulating osteoclast-mediated osteolytic bone metastasis of breast cancer.

Original language	English
Pages (from-to)	231-245
Number of pages	15
Journal	Journal of Cellular Physiology
Volume	234
Issue number	1
DOIs	https://doi.org/10.1002/jcp.26856
Publication status	Published - Jan 2018

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jcp.26856

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@article{6d24eb080e004e6687bbb6bc941c0ee8,

title = "MiR-214 is an important regulator of the musculoskeletal metabolism and disease",

abstract = "MiR-214 belongs to a family of microRNA (small, highly conserved noncoding RNA molecules) precursors that play a pivotal role in biological functions, such as cellular function, tissue development, tissue homeostasis, and pathogenesis of diseases. Recently, miR-214 emerged as a critical regulator of musculoskeletal metabolism. Specifically, miR-214 can mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration, and differentiation. MiR-214 also modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes; promotes osteoclast activity by targeting phosphatase and tensin homolog (Pten); and mediates osteoclast-osteoblast intercellular crosstalk via an exosomal miRNA paracrine mechanism. Importantly, dysregulation in miR-214 expression is associated with pathological bone conditions such as osteoporosis, osteosarcoma, multiple myeloma, and osteolytic bone metastasis of breast cancer. This review discusses the cellular targets of miR-214 in bone, the molecular mechanisms governing the activities of miR-214 in the musculoskeletal system, and the putative role of miR-214 in skeletal diseases. Understanding the biology of miR-214 could potentially lead to the development of miR-214 as a possible biomarker and a therapeutic target for musculoskeletal diseases.HighlightsMiR-214 is an important regulator of the musculoskeletal system and is involved in muscle development, bone homeostasis and bone-related disorders.MiR-214 is able to mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration and differentiation.MiR-214 modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes.MiR-214 promotes osteoclast activity by targeting specific genes and mediates osteoblast-osteoclast intercellular crosstalk via an exosomal miRNA paracrine mechanism.Dysregulation in miR-214 expression has been associated with bone diseases such as osteoporosis, osteosarcoma and multiple myeloma.Osteoclastic miR-214 is involved in regulating osteoclast-mediated osteolytic bone metastasis of breast cancer.",

keywords = "breast cancer, miR-214, multiple myeloma (MM), muscle, osteoblast, osteoclast, osteoporosis, osteosarcoma (OS), MESENCHYMAL STEM-CELLS, OSTEOLYTIC BONE METASTASIS, OSTEOSARCOMA TUMOR-GROWTH, EXOSOME-MEDIATED TRANSFER, SKELETAL-MUSCLE, OSTEOCLAST DIFFERENTIATION, OSTEOGENIC DIFFERENTIATION, TRANSCRIPTION FACTOR, IN-VITRO, MICRORNA EXPRESSION",

author = "Youqiang Sun and Vincent Kuek and Yuhao Liu and Jennifer Tickner and Yu Yuan and Leilei Chen and Zhikui Zeng and Min Shao and Wei He and Jiake Xu",

year = "2018",

month = jan,

doi = "10.1002/jcp.26856",

language = "English",

volume = "234",

pages = "231--245",

journal = "Journal of Cellular Physiology",

issn = "0021-9541",

publisher = "John Wiley & Sons",

number = "1",

}

TY - JOUR

T1 - MiR-214 is an important regulator of the musculoskeletal metabolism and disease

AU - Sun, Youqiang

AU - Kuek, Vincent

AU - Liu, Yuhao

AU - Tickner, Jennifer

AU - Yuan, Yu

AU - Chen, Leilei

AU - Zeng, Zhikui

AU - Shao, Min

AU - He, Wei

AU - Xu, Jiake

PY - 2018/1

Y1 - 2018/1

N2 - MiR-214 belongs to a family of microRNA (small, highly conserved noncoding RNA molecules) precursors that play a pivotal role in biological functions, such as cellular function, tissue development, tissue homeostasis, and pathogenesis of diseases. Recently, miR-214 emerged as a critical regulator of musculoskeletal metabolism. Specifically, miR-214 can mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration, and differentiation. MiR-214 also modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes; promotes osteoclast activity by targeting phosphatase and tensin homolog (Pten); and mediates osteoclast-osteoblast intercellular crosstalk via an exosomal miRNA paracrine mechanism. Importantly, dysregulation in miR-214 expression is associated with pathological bone conditions such as osteoporosis, osteosarcoma, multiple myeloma, and osteolytic bone metastasis of breast cancer. This review discusses the cellular targets of miR-214 in bone, the molecular mechanisms governing the activities of miR-214 in the musculoskeletal system, and the putative role of miR-214 in skeletal diseases. Understanding the biology of miR-214 could potentially lead to the development of miR-214 as a possible biomarker and a therapeutic target for musculoskeletal diseases.HighlightsMiR-214 is an important regulator of the musculoskeletal system and is involved in muscle development, bone homeostasis and bone-related disorders.MiR-214 is able to mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration and differentiation.MiR-214 modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes.MiR-214 promotes osteoclast activity by targeting specific genes and mediates osteoblast-osteoclast intercellular crosstalk via an exosomal miRNA paracrine mechanism.Dysregulation in miR-214 expression has been associated with bone diseases such as osteoporosis, osteosarcoma and multiple myeloma.Osteoclastic miR-214 is involved in regulating osteoclast-mediated osteolytic bone metastasis of breast cancer.

AB - MiR-214 belongs to a family of microRNA (small, highly conserved noncoding RNA molecules) precursors that play a pivotal role in biological functions, such as cellular function, tissue development, tissue homeostasis, and pathogenesis of diseases. Recently, miR-214 emerged as a critical regulator of musculoskeletal metabolism. Specifically, miR-214 can mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration, and differentiation. MiR-214 also modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes; promotes osteoclast activity by targeting phosphatase and tensin homolog (Pten); and mediates osteoclast-osteoblast intercellular crosstalk via an exosomal miRNA paracrine mechanism. Importantly, dysregulation in miR-214 expression is associated with pathological bone conditions such as osteoporosis, osteosarcoma, multiple myeloma, and osteolytic bone metastasis of breast cancer. This review discusses the cellular targets of miR-214 in bone, the molecular mechanisms governing the activities of miR-214 in the musculoskeletal system, and the putative role of miR-214 in skeletal diseases. Understanding the biology of miR-214 could potentially lead to the development of miR-214 as a possible biomarker and a therapeutic target for musculoskeletal diseases.HighlightsMiR-214 is an important regulator of the musculoskeletal system and is involved in muscle development, bone homeostasis and bone-related disorders.MiR-214 is able to mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration and differentiation.MiR-214 modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast-related genes.MiR-214 promotes osteoclast activity by targeting specific genes and mediates osteoblast-osteoclast intercellular crosstalk via an exosomal miRNA paracrine mechanism.Dysregulation in miR-214 expression has been associated with bone diseases such as osteoporosis, osteosarcoma and multiple myeloma.Osteoclastic miR-214 is involved in regulating osteoclast-mediated osteolytic bone metastasis of breast cancer.

KW - breast cancer

KW - miR-214

KW - multiple myeloma (MM)

KW - muscle

KW - osteoblast

KW - osteoclast

KW - osteoporosis

KW - osteosarcoma (OS)

KW - MESENCHYMAL STEM-CELLS

KW - OSTEOLYTIC BONE METASTASIS

KW - OSTEOSARCOMA TUMOR-GROWTH

KW - EXOSOME-MEDIATED TRANSFER

KW - SKELETAL-MUSCLE

KW - OSTEOCLAST DIFFERENTIATION

KW - OSTEOGENIC DIFFERENTIATION

KW - TRANSCRIPTION FACTOR

KW - IN-VITRO

KW - MICRORNA EXPRESSION

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U2 - 10.1002/jcp.26856

DO - 10.1002/jcp.26856

M3 - Review article

C2 - 30076721

SN - 0021-9541

VL - 234

SP - 231

EP - 245

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

IS - 1

ER -

MiR-214 is an important regulator of the musculoskeletal metabolism and disease

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Furin: Carving-up vital substrates for bone remodelling and homeostasis

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MiR-214 is an important regulator of the musculoskeletal metabolism and disease

Abstract

UN SDGs

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Furin: Carving-up vital substrates for bone remodelling and homeostasis

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