TY - JOUR
T1 - Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments
T2 - a proposed reporting standard for spinal cord injury experiments
AU - MIASCI Consortium
AU - Lemmon, Vance P
AU - Ferguson, Adam R
AU - Popovich, Phillip G
AU - Xu, Xiao-Ming
AU - Snow, Diane M
AU - Igarashi, Michihiro
AU - Beattie, Christine E
AU - Bixby, John L
AU - Dunlop, Sarah
PY - 2014/8/1
Y1 - 2014/8/1
N2 - The lack of reproducibility in many areas of experimental science has a number of causes, including a lack of transparency and precision in the description of experimental approaches. This has far-reaching consequences, including wasted resources and slowing of progress. Additionally, the large number of laboratories around the world publishing articles on a given topic make it difficult, if not impossible, for individual researchers to read all of the relevant literature. Consequently, centralized databases are needed to facilitate the generation of new hypotheses for testing. One strategy to improve transparency in experimental description, and to allow the development of frameworks for computer-readable knowledge repositories, is the adoption of uniform reporting standards, such as common data elements (data elements used in multiple clinical studies) and minimum information standards. This article describes a minimum information standard for spinal cord injury (SCI) experiments, its major elements, and the approaches used to develop it. Transparent reporting standards for experiments using animal models of human SCI aim to reduce inherent bias and increase experimental value.
AB - The lack of reproducibility in many areas of experimental science has a number of causes, including a lack of transparency and precision in the description of experimental approaches. This has far-reaching consequences, including wasted resources and slowing of progress. Additionally, the large number of laboratories around the world publishing articles on a given topic make it difficult, if not impossible, for individual researchers to read all of the relevant literature. Consequently, centralized databases are needed to facilitate the generation of new hypotheses for testing. One strategy to improve transparency in experimental description, and to allow the development of frameworks for computer-readable knowledge repositories, is the adoption of uniform reporting standards, such as common data elements (data elements used in multiple clinical studies) and minimum information standards. This article describes a minimum information standard for spinal cord injury (SCI) experiments, its major elements, and the approaches used to develop it. Transparent reporting standards for experiments using animal models of human SCI aim to reduce inherent bias and increase experimental value.
KW - Animals
KW - Disease Models, Animal
KW - Research Design/standards
KW - Spinal Cord Injuries
U2 - 10.1089/neu.2014.3400
DO - 10.1089/neu.2014.3400
M3 - Article
C2 - 24870067
SN - 0897-7151
VL - 31
SP - 1354
EP - 1361
JO - Journal of Neurotrauma
JF - Journal of Neurotrauma
IS - 15
ER -