Minimum Information about a Biosynthetic Gene cluster

M.H. Medema; R. Kottmann; P. Yilmaz; M. Cummings; J.B. Biggins; K. Blin; I. De Bruijn; Heng Chooi; J. Claesen; R.C. Coates; P. Cruz-Morales; S. Duddela; S. Düsterhus; D.J. Edwards; D.P. Fewer; N. Garg; C. Geiger; J.P. Gomez-Escribano; A. Greule; M. Hadjithomas; A.S. Haines; E.J.N. Helfrich; M.L. Hillwig; K. Ishida; A.C. Jones; C.S. Jones; K. Jungmann; C. Kegler; H.U. Kim; P. Kötter; D. Krug; J. Masschelein; A.V. Melnik; S.M. Mantovani; E.A. Monroe; M. Moore; N. Moss; H.W. Nützmann; G. Pan; A. Pati; D. Petras; F.J. Reen; F. Rosconi; Z. Rui; Z. Tian; N.J. Tobias; Y. Tsunematsu; P. Wiemann; E. Wyckoff; X. Yan; G. Yim; F. Yu; Y. Xie; B. Aigle; A.K. Apel; C.J. Balibar; E.P. Balskus; F. Barona-Gómez; A. Bechthold; H.B. Bode; R. Borriss; S.F. Brady; A.A. Brakhage; P. Caffrey; Y.Q. Cheng; J. Clardy; R.J. Cox; R. De Mot; S. Donadio; M.S. Donia; W.A. Van Der Donk; P.C. Dorrestein; S. Doyle; A.J.M. Driessen; M. Ehling-Schulz; K.D. Entian; M.A. Fischbach; L. Gerwick; W.H. Gerwick; H. Gross

doi:10.1038/nchembio.1890

Minimum Information about a Biosynthetic Gene cluster

M.H. Medema
, R. Kottmann
, P. Yilmaz
, M. Cummings
, J.B. Biggins
, K. Blin
, I. De Bruijn
, Heng Chooi
, J. Claesen
, R.C. Coates
, P. Cruz-Morales
, S. Duddela
, S. Düsterhus
, D.J. Edwards
, D.P. Fewer
, N. Garg
, C. Geiger
, J.P. Gomez-Escribano
, A. Greule
, M. Hadjithomas

A.S. Haines, E.J.N. Helfrich, M.L. Hillwig, K. Ishida, A.C. Jones, C.S. Jones, K. Jungmann, C. Kegler, H.U. Kim, P. Kötter, D. Krug, J. Masschelein, A.V. Melnik, S.M. Mantovani, E.A. Monroe, M. Moore, N. Moss, H.W. Nützmann, G. Pan, A. Pati, D. Petras, F.J. Reen, F. Rosconi, Z. Rui, Z. Tian, N.J. Tobias, Y. Tsunematsu, P. Wiemann, E. Wyckoff, X. Yan, G. Yim, F. Yu, Y. Xie, B. Aigle, A.K. Apel, C.J. Balibar, E.P. Balskus, F. Barona-Gómez, A. Bechthold, H.B. Bode, R. Borriss, S.F. Brady, A.A. Brakhage, P. Caffrey, Y.Q. Cheng, J. Clardy, R.J. Cox, R. De Mot, S. Donadio, M.S. Donia, W.A. Van Der Donk, P.C. Dorrestein, S. Doyle, A.J.M. Driessen, M. Ehling-Schulz, K.D. Entian, M.A. Fischbach, L. Gerwick, W.H. Gerwick, H. Gross

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

747 Citations (Scopus)

Abstract

© 2015 Nature America, Inc. All rights reserved. A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

Original language	English
Pages (from-to)	625-631
Journal	Nature Chemical Biology
Volume	11
Issue number	9
DOIs	https://doi.org/10.1038/nchembio.1890
Publication status	Published - 2015

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10.1038/nchembio.1890

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Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., ... Gross, H. (2015). Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology, 11(9), 625-631. https://doi.org/10.1038/nchembio.1890

@article{69f20c6f6818448db239cec2524e041c,

title = "Minimum Information about a Biosynthetic Gene cluster",

abstract = "{\textcopyright} 2015 Nature America, Inc. All rights reserved. A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.",

author = "M.H. Medema and R. Kottmann and P. Yilmaz and M. Cummings and J.B. Biggins and K. Blin and \{De Bruijn\}, I. and Heng Chooi and J. Claesen and R.C. Coates and P. Cruz-Morales and S. Duddela and S. D{\"u}sterhus and D.J. Edwards and D.P. Fewer and N. Garg and C. Geiger and J.P. Gomez-Escribano and A. Greule and M. Hadjithomas and A.S. Haines and E.J.N. Helfrich and M.L. Hillwig and K. Ishida and A.C. Jones and C.S. Jones and K. Jungmann and C. Kegler and H.U. Kim and P. K{\"o}tter and D. Krug and J. Masschelein and A.V. Melnik and S.M. Mantovani and E.A. Monroe and M. Moore and N. Moss and H.W. N{\"u}tzmann and G. Pan and A. Pati and D. Petras and F.J. Reen and F. Rosconi and Z. Rui and Z. Tian and N.J. Tobias and Y. Tsunematsu and P. Wiemann and E. Wyckoff and X. Yan and G. Yim and F. Yu and Y. Xie and B. Aigle and A.K. Apel and C.J. Balibar and E.P. Balskus and F. Barona-G{\'o}mez and A. Bechthold and H.B. Bode and R. Borriss and S.F. Brady and A.A. Brakhage and P. Caffrey and Y.Q. Cheng and J. Clardy and R.J. Cox and \{De Mot\}, R. and S. Donadio and M.S. Donia and \{Van Der Donk\}, W.A. and P.C. Dorrestein and S. Doyle and A.J.M. Driessen and M. Ehling-Schulz and K.D. Entian and M.A. Fischbach and L. Gerwick and W.H. Gerwick and H. Gross",

year = "2015",

doi = "10.1038/nchembio.1890",

language = "English",

volume = "11",

pages = "625--631",

journal = "Nature Chemical Biology",

issn = "1552-4450",

publisher = "Nature Research",

number = "9",

}

Medema, MH, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, JB, Blin, K, De Bruijn, I, Chooi, H, Claesen, J, Coates, RC, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, DJ, Fewer, DP, Garg, N, Geiger, C, Gomez-Escribano, JP, Greule, A, Hadjithomas, M, Haines, AS, Helfrich, EJN, Hillwig, ML, Ishida, K, Jones, AC, Jones, CS, Jungmann, K, Kegler, C, Kim, HU, Kötter, P, Krug, D, Masschelein, J, Melnik, AV, Mantovani, SM, Monroe, EA, Moore, M, Moss, N, Nützmann, HW, Pan, G, Pati, A, Petras, D, Reen, FJ, Rosconi, F, Rui, Z, Tian, Z, Tobias, NJ, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, AK, Balibar, CJ, Balskus, EP, Barona-Gómez, F, Bechthold, A, Bode, HB, Borriss, R, Brady, SF, Brakhage, AA, Caffrey, P, Cheng, YQ, Clardy, J, Cox, RJ, De Mot, R, Donadio, S, Donia, MS, Van Der Donk, WA, Dorrestein, PC, Doyle, S, Driessen, AJM, Ehling-Schulz, M, Entian, KD, Fischbach, MA, Gerwick, L, Gerwick, WH & Gross, H 2015, 'Minimum Information about a Biosynthetic Gene cluster', Nature Chemical Biology, vol. 11, no. 9, pp. 625-631. https://doi.org/10.1038/nchembio.1890

TY - JOUR

T1 - Minimum Information about a Biosynthetic Gene cluster

AU - Medema, M.H.

AU - Kottmann, R.

AU - Yilmaz, P.

AU - Cummings, M.

AU - Biggins, J.B.

AU - Blin, K.

AU - De Bruijn, I.

AU - Chooi, Heng

AU - Claesen, J.

AU - Coates, R.C.

AU - Cruz-Morales, P.

AU - Duddela, S.

AU - Düsterhus, S.

AU - Edwards, D.J.

AU - Fewer, D.P.

AU - Garg, N.

AU - Geiger, C.

AU - Gomez-Escribano, J.P.

AU - Greule, A.

AU - Hadjithomas, M.

AU - Haines, A.S.

AU - Helfrich, E.J.N.

AU - Hillwig, M.L.

AU - Ishida, K.

AU - Jones, A.C.

AU - Jones, C.S.

AU - Jungmann, K.

AU - Kegler, C.

AU - Kim, H.U.

AU - Kötter, P.

AU - Krug, D.

AU - Masschelein, J.

AU - Melnik, A.V.

AU - Mantovani, S.M.

AU - Monroe, E.A.

AU - Moore, M.

AU - Moss, N.

AU - Nützmann, H.W.

AU - Pan, G.

AU - Pati, A.

AU - Petras, D.

AU - Reen, F.J.

AU - Rosconi, F.

AU - Rui, Z.

AU - Tian, Z.

AU - Tobias, N.J.

AU - Tsunematsu, Y.

AU - Wiemann, P.

AU - Wyckoff, E.

AU - Yan, X.

AU - Yim, G.

AU - Yu, F.

AU - Xie, Y.

AU - Aigle, B.

AU - Apel, A.K.

AU - Balibar, C.J.

AU - Balskus, E.P.

AU - Barona-Gómez, F.

AU - Bechthold, A.

AU - Bode, H.B.

AU - Borriss, R.

AU - Brady, S.F.

AU - Brakhage, A.A.

AU - Caffrey, P.

AU - Cheng, Y.Q.

AU - Clardy, J.

AU - Cox, R.J.

AU - De Mot, R.

AU - Donadio, S.

AU - Donia, M.S.

AU - Van Der Donk, W.A.

AU - Dorrestein, P.C.

AU - Doyle, S.

AU - Driessen, A.J.M.

AU - Ehling-Schulz, M.

AU - Entian, K.D.

AU - Fischbach, M.A.

AU - Gerwick, L.

AU - Gerwick, W.H.

AU - Gross, H.

PY - 2015

Y1 - 2015

N2 - © 2015 Nature America, Inc. All rights reserved. A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

AB - © 2015 Nature America, Inc. All rights reserved. A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

U2 - 10.1038/nchembio.1890

DO - 10.1038/nchembio.1890

M3 - Article

C2 - 26284661

SN - 1552-4450

VL - 11

SP - 625

EP - 631

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 9

ER -

Minimum Information about a Biosynthetic Gene cluster

Abstract

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