Minimum Information about a Biosynthetic Gene cluster

M.H. Medema, R. Kottmann, P. Yilmaz, M. Cummings, J.B. Biggins, K. Blin, I. De Bruijn, Heng Chooi, J. Claesen, R.C. Coates, P. Cruz-Morales, S. Duddela, S. Düsterhus, D.J. Edwards, D.P. Fewer, N. Garg, C. Geiger, J.P. Gomez-Escribano, A. Greule, M. Hadjithomas & 60 others A.S. Haines, E.J.N. Helfrich, M.L. Hillwig, K. Ishida, A.C. Jones, C.S. Jones, K. Jungmann, C. Kegler, H.U. Kim, P. Kötter, D. Krug, J. Masschelein, A.V. Melnik, S.M. Mantovani, E.A. Monroe, M. Moore, N. Moss, H.W. Nützmann, G. Pan, A. Pati, D. Petras, F.J. Reen, F. Rosconi, Z. Rui, Z. Tian, N.J. Tobias, Y. Tsunematsu, P. Wiemann, E. Wyckoff, X. Yan, G. Yim, F. Yu, Y. Xie, B. Aigle, A.K. Apel, C.J. Balibar, E.P. Balskus, F. Barona-Gómez, A. Bechthold, H.B. Bode, R. Borriss, S.F. Brady, A.A. Brakhage, P. Caffrey, Y.Q. Cheng, J. Clardy, R.J. Cox, R. De Mot, S. Donadio, M.S. Donia, W.A. Van Der Donk, P.C. Dorrestein, S. Doyle, A.J.M. Driessen, M. Ehling-Schulz, K.D. Entian, M.A. Fischbach, L. Gerwick, W.H. Gerwick, H. Gross

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Abstract

© 2015 Nature America, Inc. All rights reserved. A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
Original languageEnglish
Pages (from-to)625-631
JournalNature Chemical Biology
Volume11
Issue number9
DOIs
Publication statusPublished - 2015

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Multigene Family
Information Storage and Retrieval
Fungi
Bacteria

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Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., ... Gross, H. (2015). Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology, 11(9), 625-631. https://doi.org/10.1038/nchembio.1890
Medema, M.H. ; Kottmann, R. ; Yilmaz, P. ; Cummings, M. ; Biggins, J.B. ; Blin, K. ; De Bruijn, I. ; Chooi, Heng ; Claesen, J. ; Coates, R.C. ; Cruz-Morales, P. ; Duddela, S. ; Düsterhus, S. ; Edwards, D.J. ; Fewer, D.P. ; Garg, N. ; Geiger, C. ; Gomez-Escribano, J.P. ; Greule, A. ; Hadjithomas, M. ; Haines, A.S. ; Helfrich, E.J.N. ; Hillwig, M.L. ; Ishida, K. ; Jones, A.C. ; Jones, C.S. ; Jungmann, K. ; Kegler, C. ; Kim, H.U. ; Kötter, P. ; Krug, D. ; Masschelein, J. ; Melnik, A.V. ; Mantovani, S.M. ; Monroe, E.A. ; Moore, M. ; Moss, N. ; Nützmann, H.W. ; Pan, G. ; Pati, A. ; Petras, D. ; Reen, F.J. ; Rosconi, F. ; Rui, Z. ; Tian, Z. ; Tobias, N.J. ; Tsunematsu, Y. ; Wiemann, P. ; Wyckoff, E. ; Yan, X. ; Yim, G. ; Yu, F. ; Xie, Y. ; Aigle, B. ; Apel, A.K. ; Balibar, C.J. ; Balskus, E.P. ; Barona-Gómez, F. ; Bechthold, A. ; Bode, H.B. ; Borriss, R. ; Brady, S.F. ; Brakhage, A.A. ; Caffrey, P. ; Cheng, Y.Q. ; Clardy, J. ; Cox, R.J. ; De Mot, R. ; Donadio, S. ; Donia, M.S. ; Van Der Donk, W.A. ; Dorrestein, P.C. ; Doyle, S. ; Driessen, A.J.M. ; Ehling-Schulz, M. ; Entian, K.D. ; Fischbach, M.A. ; Gerwick, L. ; Gerwick, W.H. ; Gross, H. / Minimum Information about a Biosynthetic Gene cluster. In: Nature Chemical Biology. 2015 ; Vol. 11, No. 9. pp. 625-631.
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Medema, MH, Kottmann, R, Yilmaz, P, Cummings, M, Biggins, JB, Blin, K, De Bruijn, I, Chooi, H, Claesen, J, Coates, RC, Cruz-Morales, P, Duddela, S, Düsterhus, S, Edwards, DJ, Fewer, DP, Garg, N, Geiger, C, Gomez-Escribano, JP, Greule, A, Hadjithomas, M, Haines, AS, Helfrich, EJN, Hillwig, ML, Ishida, K, Jones, AC, Jones, CS, Jungmann, K, Kegler, C, Kim, HU, Kötter, P, Krug, D, Masschelein, J, Melnik, AV, Mantovani, SM, Monroe, EA, Moore, M, Moss, N, Nützmann, HW, Pan, G, Pati, A, Petras, D, Reen, FJ, Rosconi, F, Rui, Z, Tian, Z, Tobias, NJ, Tsunematsu, Y, Wiemann, P, Wyckoff, E, Yan, X, Yim, G, Yu, F, Xie, Y, Aigle, B, Apel, AK, Balibar, CJ, Balskus, EP, Barona-Gómez, F, Bechthold, A, Bode, HB, Borriss, R, Brady, SF, Brakhage, AA, Caffrey, P, Cheng, YQ, Clardy, J, Cox, RJ, De Mot, R, Donadio, S, Donia, MS, Van Der Donk, WA, Dorrestein, PC, Doyle, S, Driessen, AJM, Ehling-Schulz, M, Entian, KD, Fischbach, MA, Gerwick, L, Gerwick, WH & Gross, H 2015, 'Minimum Information about a Biosynthetic Gene cluster' Nature Chemical Biology, vol. 11, no. 9, pp. 625-631. https://doi.org/10.1038/nchembio.1890

Minimum Information about a Biosynthetic Gene cluster. / Medema, M.H.; Kottmann, R.; Yilmaz, P.; Cummings, M.; Biggins, J.B.; Blin, K.; De Bruijn, I.; Chooi, Heng; Claesen, J.; Coates, R.C.; Cruz-Morales, P.; Duddela, S.; Düsterhus, S.; Edwards, D.J.; Fewer, D.P.; Garg, N.; Geiger, C.; Gomez-Escribano, J.P.; Greule, A.; Hadjithomas, M.; Haines, A.S.; Helfrich, E.J.N.; Hillwig, M.L.; Ishida, K.; Jones, A.C.; Jones, C.S.; Jungmann, K.; Kegler, C.; Kim, H.U.; Kötter, P.; Krug, D.; Masschelein, J.; Melnik, A.V.; Mantovani, S.M.; Monroe, E.A.; Moore, M.; Moss, N.; Nützmann, H.W.; Pan, G.; Pati, A.; Petras, D.; Reen, F.J.; Rosconi, F.; Rui, Z.; Tian, Z.; Tobias, N.J.; Tsunematsu, Y.; Wiemann, P.; Wyckoff, E.; Yan, X.; Yim, G.; Yu, F.; Xie, Y.; Aigle, B.; Apel, A.K.; Balibar, C.J.; Balskus, E.P.; Barona-Gómez, F.; Bechthold, A.; Bode, H.B.; Borriss, R.; Brady, S.F.; Brakhage, A.A.; Caffrey, P.; Cheng, Y.Q.; Clardy, J.; Cox, R.J.; De Mot, R.; Donadio, S.; Donia, M.S.; Van Der Donk, W.A.; Dorrestein, P.C.; Doyle, S.; Driessen, A.J.M.; Ehling-Schulz, M.; Entian, K.D.; Fischbach, M.A.; Gerwick, L.; Gerwick, W.H.; Gross, H.

In: Nature Chemical Biology, Vol. 11, No. 9, 2015, p. 625-631.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Minimum Information about a Biosynthetic Gene cluster

AU - Medema, M.H.

AU - Kottmann, R.

AU - Yilmaz, P.

AU - Cummings, M.

AU - Biggins, J.B.

AU - Blin, K.

AU - De Bruijn, I.

AU - Chooi, Heng

AU - Claesen, J.

AU - Coates, R.C.

AU - Cruz-Morales, P.

AU - Duddela, S.

AU - Düsterhus, S.

AU - Edwards, D.J.

AU - Fewer, D.P.

AU - Garg, N.

AU - Geiger, C.

AU - Gomez-Escribano, J.P.

AU - Greule, A.

AU - Hadjithomas, M.

AU - Haines, A.S.

AU - Helfrich, E.J.N.

AU - Hillwig, M.L.

AU - Ishida, K.

AU - Jones, A.C.

AU - Jones, C.S.

AU - Jungmann, K.

AU - Kegler, C.

AU - Kim, H.U.

AU - Kötter, P.

AU - Krug, D.

AU - Masschelein, J.

AU - Melnik, A.V.

AU - Mantovani, S.M.

AU - Monroe, E.A.

AU - Moore, M.

AU - Moss, N.

AU - Nützmann, H.W.

AU - Pan, G.

AU - Pati, A.

AU - Petras, D.

AU - Reen, F.J.

AU - Rosconi, F.

AU - Rui, Z.

AU - Tian, Z.

AU - Tobias, N.J.

AU - Tsunematsu, Y.

AU - Wiemann, P.

AU - Wyckoff, E.

AU - Yan, X.

AU - Yim, G.

AU - Yu, F.

AU - Xie, Y.

AU - Aigle, B.

AU - Apel, A.K.

AU - Balibar, C.J.

AU - Balskus, E.P.

AU - Barona-Gómez, F.

AU - Bechthold, A.

AU - Bode, H.B.

AU - Borriss, R.

AU - Brady, S.F.

AU - Brakhage, A.A.

AU - Caffrey, P.

AU - Cheng, Y.Q.

AU - Clardy, J.

AU - Cox, R.J.

AU - De Mot, R.

AU - Donadio, S.

AU - Donia, M.S.

AU - Van Der Donk, W.A.

AU - Dorrestein, P.C.

AU - Doyle, S.

AU - Driessen, A.J.M.

AU - Ehling-Schulz, M.

AU - Entian, K.D.

AU - Fischbach, M.A.

AU - Gerwick, L.

AU - Gerwick, W.H.

AU - Gross, H.

PY - 2015

Y1 - 2015

N2 - © 2015 Nature America, Inc. All rights reserved. A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

AB - © 2015 Nature America, Inc. All rights reserved. A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.

U2 - 10.1038/nchembio.1890

DO - 10.1038/nchembio.1890

M3 - Article

VL - 11

SP - 625

EP - 631

JO - Nature Chemical Biology

JF - Nature Chemical Biology

SN - 1552-4450

IS - 9

ER -

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 2015;11(9):625-631. https://doi.org/10.1038/nchembio.1890