Minimal-deviation Endometrioid Adenocarcinoma of the Cervix: A Case Report with Ultrastructural Analysis Demonstrating Abnormal Ciliation of the Tumor Cells

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    Abstract

    Minimal-deviation endometrioid adenocarcinoma (MDEA) of the uterine cervix is a rare tumor that may be confused histologically with a number of benign lesions as well as other types of endocervical neoplasia. The histologic and immunohistochemical features of MDEA have been described in case reports and in small series, but correlation of these findings with ultrastructural examination has not been documented. Herein we report a 51-yr-old patient who underwent hysterectomy for menorrhagia and was found to have a clinically unsuspected, stage IB cervical MDEA. The light microscopic, immunohistochemical, and electron microscopic features of the tumor are described, with the most significant ultrastructural abnormality being the presence of abnormal cilia and ciliogenesis.

    Original languageEnglish
    Pages (from-to)90-94
    Number of pages5
    JournalInternational Journal of Gynecological Pathology
    Volume36
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2017

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    Endometrioid Carcinoma
    Cervix Uteri
    Menorrhagia
    Neoplasms
    Cilia
    Hysterectomy
    Electrons
    Light

    Cite this

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    title = "Minimal-deviation Endometrioid Adenocarcinoma of the Cervix: A Case Report with Ultrastructural Analysis Demonstrating Abnormal Ciliation of the Tumor Cells",
    abstract = "Minimal-deviation endometrioid adenocarcinoma (MDEA) of the uterine cervix is a rare tumor that may be confused histologically with a number of benign lesions as well as other types of endocervical neoplasia. The histologic and immunohistochemical features of MDEA have been described in case reports and in small series, but correlation of these findings with ultrastructural examination has not been documented. Herein we report a 51-yr-old patient who underwent hysterectomy for menorrhagia and was found to have a clinically unsuspected, stage IB cervical MDEA. The light microscopic, immunohistochemical, and electron microscopic features of the tumor are described, with the most significant ultrastructural abnormality being the presence of abnormal cilia and ciliogenesis.",
    keywords = "Adenocarcinoma, Cervix, Electron microscopy, Endometrioid, Immunohistochemistry, Minimal deviation",
    author = "Gould, {Paul R.} and Stewart, {Colin J R} and Papadimitriou, {John M.}",
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    TY - JOUR

    T1 - Minimal-deviation Endometrioid Adenocarcinoma of the Cervix

    T2 - A Case Report with Ultrastructural Analysis Demonstrating Abnormal Ciliation of the Tumor Cells

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    AU - Stewart, Colin J R

    AU - Papadimitriou, John M.

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    N2 - Minimal-deviation endometrioid adenocarcinoma (MDEA) of the uterine cervix is a rare tumor that may be confused histologically with a number of benign lesions as well as other types of endocervical neoplasia. The histologic and immunohistochemical features of MDEA have been described in case reports and in small series, but correlation of these findings with ultrastructural examination has not been documented. Herein we report a 51-yr-old patient who underwent hysterectomy for menorrhagia and was found to have a clinically unsuspected, stage IB cervical MDEA. The light microscopic, immunohistochemical, and electron microscopic features of the tumor are described, with the most significant ultrastructural abnormality being the presence of abnormal cilia and ciliogenesis.

    AB - Minimal-deviation endometrioid adenocarcinoma (MDEA) of the uterine cervix is a rare tumor that may be confused histologically with a number of benign lesions as well as other types of endocervical neoplasia. The histologic and immunohistochemical features of MDEA have been described in case reports and in small series, but correlation of these findings with ultrastructural examination has not been documented. Herein we report a 51-yr-old patient who underwent hysterectomy for menorrhagia and was found to have a clinically unsuspected, stage IB cervical MDEA. The light microscopic, immunohistochemical, and electron microscopic features of the tumor are described, with the most significant ultrastructural abnormality being the presence of abnormal cilia and ciliogenesis.

    KW - Adenocarcinoma

    KW - Cervix

    KW - Electron microscopy

    KW - Endometrioid

    KW - Immunohistochemistry

    KW - Minimal deviation

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