Millimeter waves alter DNA secondary structures and modulate the transcriptome in human fibroblasts

Nicholas B. Lawler; Cameron W. Evans; Sergii Romanenko; Nutan Chaudhari; Mark Fear; Fiona Wood; Nicole M. Smith; Vincent P. Wallace; K. Swaminathan Iyer

doi:10.1364/BOE.458478

Millimeter waves alter DNA secondary structures and modulate the transcriptome in human fibroblasts

Nicholas B. Lawler, Cameron W. Evans, Sergii Romanenko, Nutan Chaudhari, Mark Fear, Fiona Wood, Nicole M. Smith, Vincent P. Wallace, K. Swaminathan Iyer

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

As millimetre wave (MMW) frequencies of the electromagnetic spectrum are increasingly adopted in modern technologies such as mobile communications and networking, characterising the biological effects is critical in determining safe exposure levels. We study the exposure of primary human dermal fibroblasts to MMWs, finding MMWs trigger genomic and transcriptomic alterations. In particular, repeated 60 GHz, 2.6 mW cm⁻², 46.8 J cm⁻² d⁻¹ MMW doses induce a unique physiological response after 2 and 4 days exposure. We show that high dose MMWs induce simultaneous non-thermal alterations to the transcriptome and DNA structural dynamics, including formation of G-quadruplex and i-motif secondary structures, but not DNA damage.

Original language	English
Pages (from-to)	3131-3144
Number of pages	14
Journal	Biomedical Optics Express
Volume	13
Issue number	5
DOIs	https://doi.org/10.1364/BOE.458478
Publication status	Published - 1 May 2022

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10.1364/BOE.458478

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title = "Millimeter waves alter DNA secondary structures and modulate the transcriptome in human fibroblasts",

abstract = "As millimetre wave (MMW) frequencies of the electromagnetic spectrum are increasingly adopted in modern technologies such as mobile communications and networking, characterising the biological effects is critical in determining safe exposure levels. We study the exposure of primary human dermal fibroblasts to MMWs, finding MMWs trigger genomic and transcriptomic alterations. In particular, repeated 60 GHz, 2.6 mW cm−2, 46.8 J cm−2 d−1 MMW doses induce a unique physiological response after 2 and 4 days exposure. We show that high dose MMWs induce simultaneous non-thermal alterations to the transcriptome and DNA structural dynamics, including formation of G-quadruplex and i-motif secondary structures, but not DNA damage.",

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AU - Lawler, Nicholas B.

AU - Evans, Cameron W.

AU - Romanenko, Sergii

AU - Chaudhari, Nutan

AU - Fear, Mark

AU - Wood, Fiona

AU - Smith, Nicole M.

AU - Wallace, Vincent P.

AU - Swaminathan Iyer, K.

PY - 2022/5/1

Y1 - 2022/5/1

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AB - As millimetre wave (MMW) frequencies of the electromagnetic spectrum are increasingly adopted in modern technologies such as mobile communications and networking, characterising the biological effects is critical in determining safe exposure levels. We study the exposure of primary human dermal fibroblasts to MMWs, finding MMWs trigger genomic and transcriptomic alterations. In particular, repeated 60 GHz, 2.6 mW cm−2, 46.8 J cm−2 d−1 MMW doses induce a unique physiological response after 2 and 4 days exposure. We show that high dose MMWs induce simultaneous non-thermal alterations to the transcriptome and DNA structural dynamics, including formation of G-quadruplex and i-motif secondary structures, but not DNA damage.

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JO - Biomedical Optics Express

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Millimeter waves alter DNA secondary structures and modulate the transcriptome in human fibroblasts

Abstract

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Biological Applications of Terahertz Technology - from molecules to tissues

Exogenous Cell Stimulation: A Versatile Approach to Programming Gene Expression

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Millimeter waves alter DNA secondary structures and modulate the transcriptome in human fibroblasts

Abstract

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Projects

Biological Applications of Terahertz Technology - from molecules to tissues

Research output

Exogenous Cell Stimulation: A Versatile Approach to Programming Gene Expression

Cite this