Mild traumatic brain injury: a risk factor for neurodegeneration

Brandon E Gavett, Robert A Stern, Robert C Cantu, Christopher J Nowinski, Ann C McKee

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Recently, it has become clear that head trauma can lead to a progressive neurodegeneration known as chronic traumatic encephalopathy. Although the medical literature also implicates head trauma as a risk factor for Alzheimer's disease, these findings are predominantly based on clinical diagnostic criteria that lack specificity. The dementia that follows head injuries or repetitive mild trauma may be caused by chronic traumatic encephalopathy, alone or in conjunction with other neurodegenerations (for example, Alzheimer's disease). Prospective longitudinal studies of head-injured individuals, with neuropathological verification, will not only improve understanding of head trauma as a risk factor for dementia but will also enhance treatment and prevention of a variety of neurodegenerative diseases.

Original languageEnglish
Pages (from-to)18
JournalAlzheimer's Research and Therapy
Volume2
Issue number3
DOIs
Publication statusPublished - 25 Jun 2010
Externally publishedYes

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