TY - JOUR
T1 - Microvascular changes at different stages of chronic kidney disease
AU - Kannenkeril, Dennis
AU - Frost, Shaun
AU - Nolde, Janis M.
AU - Kiuchi, Márcio Galindo
AU - Carnagarin, Revathy
AU - Lugo-Gavidia, Leslie Marisol
AU - Chan, Justine
AU - Joyson, Anu
AU - Matthews, Vance B.
AU - Herat, Lakshini Y.
AU - Azzam, Omar
AU - Mehdizadeh, Maryam
AU - Vignarajan, Janardhan
AU - Kanagasingam, Yogesan
AU - Schlaich, Markus P.
PY - 2021/2
Y1 - 2021/2
N2 - Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio- and cerebrovascular events than progressing to end-stage renal disease. The authors explored whether retinal microvascular calibers differed with the degree of renal impairment and between the standard and extended optic disk and may serve as a simple additional tool for risk stratification in this highly vulnerable patient cohort. The authors analyzed central retinal arteriolar and venular equivalent calibers (CRAE, CRVE) at different retinal zones (zone B&C) using digital retinal imaging in hypertensive patients with stage 2 (n = 66) or stage 3 CKD (n = 30). Results were adjusted for age, sex, HbA1c, and 24-hour diastolic blood pressure. Mean eGFR was 77.7 ± 8.9 and 48.8 ± 7.9 ml/min/1.73 m2 for stage 2 and 3 CKD, respectively. CRAE and CRVE in zones B and C were significantly lower in patients with stage 3 CKD compared to patients with stage 2 CKD (CRAE-B:141.1 ± 21.4 vs. 130.5 ± 18.9 µm, p =.030; CRAE-C:137.4 ± 19.4 vs 129.2 ± 18.2 µm, p =.049; CRVE-B:220.8 ± 33.0 vs. 206.0 ± 28.4 µm, p =.004; and CRVE-C:215.9 ± 33.0 vs. 201.2 ± 25.1µm, p =.003). In patients with stage 2 CKD, CRAE-B was higher than CRAE-C (141.1 ± 21.4 vs. 137.4 ± 19.4µm, p
AB - Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio- and cerebrovascular events than progressing to end-stage renal disease. The authors explored whether retinal microvascular calibers differed with the degree of renal impairment and between the standard and extended optic disk and may serve as a simple additional tool for risk stratification in this highly vulnerable patient cohort. The authors analyzed central retinal arteriolar and venular equivalent calibers (CRAE, CRVE) at different retinal zones (zone B&C) using digital retinal imaging in hypertensive patients with stage 2 (n = 66) or stage 3 CKD (n = 30). Results were adjusted for age, sex, HbA1c, and 24-hour diastolic blood pressure. Mean eGFR was 77.7 ± 8.9 and 48.8 ± 7.9 ml/min/1.73 m2 for stage 2 and 3 CKD, respectively. CRAE and CRVE in zones B and C were significantly lower in patients with stage 3 CKD compared to patients with stage 2 CKD (CRAE-B:141.1 ± 21.4 vs. 130.5 ± 18.9 µm, p =.030; CRAE-C:137.4 ± 19.4 vs 129.2 ± 18.2 µm, p =.049; CRVE-B:220.8 ± 33.0 vs. 206.0 ± 28.4 µm, p =.004; and CRVE-C:215.9 ± 33.0 vs. 201.2 ± 25.1µm, p =.003). In patients with stage 2 CKD, CRAE-B was higher than CRAE-C (141.1 ± 21.4 vs. 137.4 ± 19.4µm, p
KW - chronic kidney disease
KW - glomerular filtration rate
KW - microvascular change
KW - retinal vessel caliber hypertension sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=85097766621&partnerID=8YFLogxK
U2 - 10.1111/jch.14138
DO - 10.1111/jch.14138
M3 - Article
C2 - 33340251
AN - SCOPUS:85097766621
SN - 1524-6175
VL - 23
SP - 309
EP - 316
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 2
ER -
