Abstract
Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.
Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.
Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.
Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.
Original language | English |
---|---|
Pages (from-to) | 422-431 |
Number of pages | 10 |
Journal | Current Drug Targets |
Volume | 19 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Apr 2018 |