MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Haowei Li, Zanjing Zhai, Xinhua Qu, Jiake Xu, An Qin, Kerong Dai

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.

Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.

Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.

Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

Original languageEnglish
Pages (from-to)422-431
Number of pages10
JournalCurrent Drug Targets
Volume19
Issue number5
DOIs
Publication statusPublished - 2018

Cite this

Li, Haowei ; Zhai, Zanjing ; Qu, Xinhua ; Xu, Jiake ; Qin, An ; Dai, Kerong. / MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases. In: Current Drug Targets. 2018 ; Vol. 19, No. 5. pp. 422-431.
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abstract = "Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.",
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MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases. / Li, Haowei; Zhai, Zanjing; Qu, Xinhua; Xu, Jiake; Qin, An; Dai, Kerong.

In: Current Drug Targets, Vol. 19, No. 5, 2018, p. 422-431.

Research output: Contribution to journalReview article

TY - JOUR

T1 - MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

AU - Li, Haowei

AU - Zhai, Zanjing

AU - Qu, Xinhua

AU - Xu, Jiake

AU - Qin, An

AU - Dai, Kerong

PY - 2018

Y1 - 2018

N2 - Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

AB - Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

KW - Drug targets

KW - miRNAs

KW - osteoclasts

KW - osteolytic diseases

KW - bone homeostasis

KW - biogenesis

KW - PARTICLE-INDUCED OSTEOLYSIS

KW - COLLAGEN-INDUCED ARTHRITIS

KW - NECROSIS-FACTOR-ALPHA

KW - REGULATES OSTEOCLASTOGENESIS

KW - RHEUMATOID-ARTHRITIS

KW - TRANSCRIPTION FACTOR

KW - PROTEIN INHIBITOR

KW - BONE-RESORPTION

KW - DOWN-REGULATION

KW - MESSENGER-RNAS

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DO - 10.2174/1389450117666160502144329

M3 - Review article

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JF - Current Drug Targets

SN - 1389-4501

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ER -