MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Haowei Li, Zanjing Zhai, Xinhua Qu, Jiake Xu, An Qin, Kerong Dai

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.

Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.

Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.

Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

Original languageEnglish
Pages (from-to)422-431
Number of pages10
JournalCurrent Drug Targets
Volume19
Issue number5
DOIs
Publication statusPublished - 2018

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