MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Haowei Li; Zanjing Zhai; Xinhua Qu; Jiake Xu; An Qin; Kerong Dai

doi:10.2174/1389450117666160502144329

MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Haowei Li, Zanjing Zhai, Xinhua Qu, Jiake Xu, An Qin, Kerong Dai

Research output: Contribution to journal › Review article › peer-review

9 Citations (Scopus)

Abstract

Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.

Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.

Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.

Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

Original language	English
Pages (from-to)	422-431
Number of pages	10
Journal	Current Drug Targets
Volume	19
Issue number	5
DOIs	https://doi.org/10.2174/1389450117666160502144329
Publication status	Published - 1 Apr 2018

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10.2174/1389450117666160502144329

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title = "MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases",

abstract = "Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.",

keywords = "Drug targets, miRNAs, osteoclasts, osteolytic diseases, bone homeostasis, biogenesis, PARTICLE-INDUCED OSTEOLYSIS, COLLAGEN-INDUCED ARTHRITIS, NECROSIS-FACTOR-ALPHA, REGULATES OSTEOCLASTOGENESIS, RHEUMATOID-ARTHRITIS, TRANSCRIPTION FACTOR, PROTEIN INHIBITOR, BONE-RESORPTION, DOWN-REGULATION, MESSENGER-RNAS",

author = "Haowei Li and Zanjing Zhai and Xinhua Qu and Jiake Xu and An Qin and Kerong Dai",

year = "2018",

month = apr,

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doi = "10.2174/1389450117666160502144329",

language = "English",

volume = "19",

pages = "422--431",

journal = "Current Drug Targets",

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TY - JOUR

T1 - MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

AU - Li, Haowei

AU - Zhai, Zanjing

AU - Qu, Xinhua

AU - Xu, Jiake

AU - Qin, An

AU - Dai, Kerong

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

AB - Background: Understanding the roles of miRNAs in osteoclasts has great potential in the diagnosis and treatment of osteolytic diseases.Objective: The purpose of this paper was to describe the current knowledge of miRNA biogenesis and summarize recent work on the roles of miRNAs in osteoclasts.Results: There is accumulating evidence to indicate that miRNAs constitute a novel and efficient mechanism for the regulation of gene expression.Conclusion: Untangling the role that miRNAs play in osteoclastogenesis will illuminate new strategies and specific drug targets for the treatment of osteolytic diseases. Many questions remain, but an in-depth comprehension of the network and kinetics of miRNAs expression, and their connection with cognate genes will not be trivial, but fruitful.

KW - Drug targets

KW - miRNAs

KW - osteoclasts

KW - osteolytic diseases

KW - bone homeostasis

KW - biogenesis

KW - PARTICLE-INDUCED OSTEOLYSIS

KW - COLLAGEN-INDUCED ARTHRITIS

KW - NECROSIS-FACTOR-ALPHA

KW - REGULATES OSTEOCLASTOGENESIS

KW - RHEUMATOID-ARTHRITIS

KW - TRANSCRIPTION FACTOR

KW - PROTEIN INHIBITOR

KW - BONE-RESORPTION

KW - DOWN-REGULATION

KW - MESSENGER-RNAS

U2 - 10.2174/1389450117666160502144329

DO - 10.2174/1389450117666160502144329

M3 - Review article

C2 - 27138766

SN - 1389-4501

VL - 19

SP - 422

EP - 431

JO - Current Drug Targets

JF - Current Drug Targets

IS - 5

ER -

MicroRNAs as Potential Targets for Treatment of Osteoclast-Related Diseases

Abstract

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