TY - JOUR
T1 - microRNA-7: a tumor suppressor miRNA with therapeutic potential
AU - Kalinowski, Felicity
AU - Brown, Rikki
AU - Ganda, Clarissa
AU - Giles, K.M.
AU - Epis, Michael
AU - Horsham, Jessica
AU - Leedman, Peter
PY - 2014/9
Y1 - 2014/9
N2 - microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, spleen and pancreas. Reduced levels of miR-7 have been linked to the development of cancer and metastasis. As a tumor suppressor, miR-7 functions to co-ordinately downregulate a number of direct (e.g. the epidermal growth factor receptor) and indirect (e.g. phospho-Akt) growth promoting targets to decrease tumor growth in vitro and in vivo. In addition, miR-7 can increase the sensitivity of treatment-resistant cancer cells to therapeutics and inhibit metastasis. These data suggest that replacement of miR-7 (‘miRNA replacement therapy’) for specific human cancers could represent a new treatment approach.
AB - microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, spleen and pancreas. Reduced levels of miR-7 have been linked to the development of cancer and metastasis. As a tumor suppressor, miR-7 functions to co-ordinately downregulate a number of direct (e.g. the epidermal growth factor receptor) and indirect (e.g. phospho-Akt) growth promoting targets to decrease tumor growth in vitro and in vivo. In addition, miR-7 can increase the sensitivity of treatment-resistant cancer cells to therapeutics and inhibit metastasis. These data suggest that replacement of miR-7 (‘miRNA replacement therapy’) for specific human cancers could represent a new treatment approach.
U2 - 10.1016/j.biocel.2014.05.040
DO - 10.1016/j.biocel.2014.05.040
M3 - Article
VL - 54
SP - 312
EP - 317
JO - The International Journal of Biochemistry & Cell Biology
JF - The International Journal of Biochemistry & Cell Biology
SN - 1357-2725
ER -