microRNA-7: a tumor suppressor miRNA with therapeutic potential

Felicity Kalinowski, Rikki Brown, Clarissa Ganda, K.M. Giles, Michael Epis, Jessica Horsham, Peter Leedman

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, spleen and pancreas. Reduced levels of miR-7 have been linked to the development of cancer and metastasis. As a tumor suppressor, miR-7 functions to co-ordinately downregulate a number of direct (e.g. the epidermal growth factor receptor) and indirect (e.g. phospho-Akt) growth promoting targets to decrease tumor growth in vitro and in vivo. In addition, miR-7 can increase the sensitivity of treatment-resistant cancer cells to therapeutics and inhibit metastasis. These data suggest that replacement of miR-7 (‘miRNA replacement therapy’) for specific human cancers could represent a new treatment approach.

Original languageEnglish
Pages (from-to)312-317
JournalInternational Journal of Biochemistry and Cell Biology
Volume54
Early online date5 Jun 2014
DOIs
Publication statusPublished - Sep 2014

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