TY - JOUR
T1 - Microbial synthetic biology for plant metabolite production
T2 - a strategy to reconcile human health with the realization of the UN Sustainable Development Goals
AU - Rojo, Fernando Perez
AU - Vuong, Paton
AU - Pillow, J. Jane
AU - Kaur, Parwinder
N1 - Funding Information:
Fernando Perez Rojo acknowledges the University of Western Australia for providing international fee‐offset scholarship and the University Postgraduate Award. Parwinder Kaur is supported by the University of Western Australia with additional research funding from ExPlanta Pty Ltd towards the Biosynthesis of Isoflavones–Formononetin (FMN) Proof of Concept project. Jane Pillow is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (GNT1196188). Open access publishing facilitated by The University of Western Australia, as part of the Wiley ‐ The University of Western Australia agreement via the Council of Australian University Librarians.
Publisher Copyright:
© 2023 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Plants produce a wide range of secondary metabolites that provide an array of benefits for human health. Challenges of native host production systems such as excessive land use, large carbon footprints, long production times, and high production costs often make plant-based production of these critical metabolites inefficient and unsustainable. Engineered production through microbial-based synthetic biology offers an alternative method of producing plant compounds that addresses the limitations encountered in plant-based production. New technological and analytical tools such as bioprospecting, machine learning, and protein modeling can be used to explore biodiversity-based data to identify more efficient enzymatic sequences for optimizing the production of plant derivatives. Ex planta production using microbial chassis systems provides a flexible, scalable metabolic platform that can more readily integrate new metabolic processes. Potential improvements include increased production rates and enhanced bioavailability of critical compounds, expanding the frontiers of metabolite production for optimized clinical applications. Microbial-based synthetic biology also opens an avenue for sustainable production, with the capability of modifying the microbial chassis to accommodate a wide variety of substrates for feedstock. It includes the utilization of waste from human activities as carbon sources for production, presenting an opportunity to use cheap renewable resources for greener production methods. The benefits of ex planta production systems can potentially enable the efficient, scalable, and sustainable production of plant derivatives that may vastly improve health and help bring forward the realization of the 2030 UN Sustainable Development Goals.
AB - Plants produce a wide range of secondary metabolites that provide an array of benefits for human health. Challenges of native host production systems such as excessive land use, large carbon footprints, long production times, and high production costs often make plant-based production of these critical metabolites inefficient and unsustainable. Engineered production through microbial-based synthetic biology offers an alternative method of producing plant compounds that addresses the limitations encountered in plant-based production. New technological and analytical tools such as bioprospecting, machine learning, and protein modeling can be used to explore biodiversity-based data to identify more efficient enzymatic sequences for optimizing the production of plant derivatives. Ex planta production using microbial chassis systems provides a flexible, scalable metabolic platform that can more readily integrate new metabolic processes. Potential improvements include increased production rates and enhanced bioavailability of critical compounds, expanding the frontiers of metabolite production for optimized clinical applications. Microbial-based synthetic biology also opens an avenue for sustainable production, with the capability of modifying the microbial chassis to accommodate a wide variety of substrates for feedstock. It includes the utilization of waste from human activities as carbon sources for production, presenting an opportunity to use cheap renewable resources for greener production methods. The benefits of ex planta production systems can potentially enable the efficient, scalable, and sustainable production of plant derivatives that may vastly improve health and help bring forward the realization of the 2030 UN Sustainable Development Goals.
KW - bioavailability
KW - metabolic engineering
KW - microbial synthetic biology
KW - plant derivatives
KW - sustainability
UR - http://www.scopus.com/inward/record.url?scp=85164923244&partnerID=8YFLogxK
U2 - 10.1002/bbb.2522
DO - 10.1002/bbb.2522
M3 - Article
AN - SCOPUS:85164923244
SN - 1932-104X
VL - 17
SP - 1485
EP - 1495
JO - Biofuels, Bioproducts and Biorefining
JF - Biofuels, Bioproducts and Biorefining
IS - 6
ER -