Microbial stimulation as an aetiologic factor in atopic disease

P.G. Holt; C. Macaubas; Susan Prescott; Peter Sly

doi:10.1111/j.1398-9995.1999.tb04382.x

Microbial stimulation as an aetiologic factor in atopic disease

P.G. Holt, C. Macaubas, Susan Prescott, Peter Sly

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of atopic diseases, particularly in the respiratory tract. Moreover, these effects may have long-lasting consequences in relation to expression of the atopic phenotype in adulthood. This review discusses key aspects of this evidence in relation to the underlying mechanisms which regulate T-helper (Th)-cell function; in particular, the generation of Th-memory cells responsive to inhalant allergens.

Original language	English
Pages (from-to)	12S-16S
Journal	Allergy
Volume	54
Issue number	Supplement 49
DOIs	https://doi.org/10.1111/j.1398-9995.1999.tb04382.x
Publication status	Published - 1999

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title = "Microbial stimulation as an aetiologic factor in atopic disease",

abstract = "Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of atopic diseases, particularly in the respiratory tract. Moreover, these effects may have long-lasting consequences in relation to expression of the atopic phenotype in adulthood. This review discusses key aspects of this evidence in relation to the underlying mechanisms which regulate T-helper (Th)-cell function; in particular, the generation of Th-memory cells responsive to inhalant allergens.",

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AU - Holt, P.G.

AU - Macaubas, C.

AU - Prescott, Susan

AU - Sly, Peter

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N2 - Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of atopic diseases, particularly in the respiratory tract. Moreover, these effects may have long-lasting consequences in relation to expression of the atopic phenotype in adulthood. This review discusses key aspects of this evidence in relation to the underlying mechanisms which regulate T-helper (Th)-cell function; in particular, the generation of Th-memory cells responsive to inhalant allergens.

AB - Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of atopic diseases, particularly in the respiratory tract. Moreover, these effects may have long-lasting consequences in relation to expression of the atopic phenotype in adulthood. This review discusses key aspects of this evidence in relation to the underlying mechanisms which regulate T-helper (Th)-cell function; in particular, the generation of Th-memory cells responsive to inhalant allergens.

U2 - 10.1111/j.1398-9995.1999.tb04382.x

DO - 10.1111/j.1398-9995.1999.tb04382.x

M3 - Article

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SP - 12S-16S

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - Supplement 49

ER -

Microbial stimulation as an aetiologic factor in atopic disease

Abstract

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