Microbial stimulation as an aetiologic factor in atopic disease

P.G. Holt, C. Macaubas, Susan Prescott, Peter Sly

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Epidemiologic evidence from various sources suggests that exposure to microbial stimuli during early childhood can influence the induction and expression of atopic diseases, particularly in the respiratory tract. Moreover, these effects may have long-lasting consequences in relation to expression of the atopic phenotype in adulthood. This review discusses key aspects of this evidence in relation to the underlying mechanisms which regulate T-helper (Th)-cell function; in particular, the generation of Th-memory cells responsive to inhalant allergens.
Original languageEnglish
Pages (from-to)12S-16S
Issue numberSupplement 49
Publication statusPublished - 1999


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