Micro-pore structures and compressive strengths of hydroxyapatite/wollastonite scaffolds prepared by freezing dry

Bin Jiang; Yuanmeng Wang; Xi Feng; Shujie Yang; Lingzhi Quan; Yidi Zhou; Junhong Chen; Minghao Fang; Zhaohui Huang; Xin Min; Xiaozhi Hu

doi:10.1177/02670836241265073

Micro-pore structures and compressive strengths of hydroxyapatite/wollastonite scaffolds prepared by freezing dry

Bin Jiang, Yuanmeng Wang, Xi Feng, Shujie Yang, Lingzhi Quan, Yidi Zhou, Junhong Chen, Minghao Fang, Zhaohui Huang, Xin Min, Xiaozhi Hu

Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Hydroxyapatite (HA) has been wildly used in clinical practice for artificial implants. However, due to its inherent properties and preparation process, it is limited by low strength in practical applications. Therefore, highly porous hydroxyapatite scaffolds reinforced with 0 to 30 wt% doped wollastonite (WS) (HA/WS) were prepared by freeze-drying in combination with pressureless sintering method. The results demonstrated that WS could consistently improve the compressive properties of HA/WS scaffolds. The HA/WS scaffolds have optimal total porosity with good open pores and internal interconnections when the WS doping is 10%. In vitro osteoclast attachment experiments indicated that the HA/WS scaffolds had good biocompatibility. The findings of this study provide theoretical guidance for the application of HA in the field of artificial implants.

Original language	English
Pages (from-to)	627-634
Number of pages	8
Journal	Materials Science and Technology (United Kingdom)
Volume	41
Issue number	9
Early online date	1 Aug 2024
DOIs	https://doi.org/10.1177/02670836241265073
Publication status	Published - Jun 2025

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title = "Micro-pore structures and compressive strengths of hydroxyapatite/wollastonite scaffolds prepared by freezing dry",

abstract = "Hydroxyapatite (HA) has been wildly used in clinical practice for artificial implants. However, due to its inherent properties and preparation process, it is limited by low strength in practical applications. Therefore, highly porous hydroxyapatite scaffolds reinforced with 0 to 30 wt% doped wollastonite (WS) (HA/WS) were prepared by freeze-drying in combination with pressureless sintering method. The results demonstrated that WS could consistently improve the compressive properties of HA/WS scaffolds. The HA/WS scaffolds have optimal total porosity with good open pores and internal interconnections when the WS doping is 10%. In vitro osteoclast attachment experiments indicated that the HA/WS scaffolds had good biocompatibility. The findings of this study provide theoretical guidance for the application of HA in the field of artificial implants.",

keywords = "bioceramics, biocompatibility, compressive strength, freeze-drying, HA/WS scaffolds",

author = "Bin Jiang and Yuanmeng Wang and Xi Feng and Shujie Yang and Lingzhi Quan and Yidi Zhou and Junhong Chen and Minghao Fang and Zhaohui Huang and Xin Min and Xiaozhi Hu",

year = "2025",

month = jun,

doi = "10.1177/02670836241265073",

language = "English",

volume = "41",

pages = "627--634",

journal = "Materials Science and Technology (United Kingdom)",

issn = "0267-0836",

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TY - JOUR

T1 - Micro-pore structures and compressive strengths of hydroxyapatite/wollastonite scaffolds prepared by freezing dry

AU - Jiang, Bin

AU - Wang, Yuanmeng

AU - Feng, Xi

AU - Yang, Shujie

AU - Quan, Lingzhi

AU - Zhou, Yidi

AU - Chen, Junhong

AU - Fang, Minghao

AU - Huang, Zhaohui

AU - Min, Xin

AU - Hu, Xiaozhi

PY - 2025/6

Y1 - 2025/6

N2 - Hydroxyapatite (HA) has been wildly used in clinical practice for artificial implants. However, due to its inherent properties and preparation process, it is limited by low strength in practical applications. Therefore, highly porous hydroxyapatite scaffolds reinforced with 0 to 30 wt% doped wollastonite (WS) (HA/WS) were prepared by freeze-drying in combination with pressureless sintering method. The results demonstrated that WS could consistently improve the compressive properties of HA/WS scaffolds. The HA/WS scaffolds have optimal total porosity with good open pores and internal interconnections when the WS doping is 10%. In vitro osteoclast attachment experiments indicated that the HA/WS scaffolds had good biocompatibility. The findings of this study provide theoretical guidance for the application of HA in the field of artificial implants.

AB - Hydroxyapatite (HA) has been wildly used in clinical practice for artificial implants. However, due to its inherent properties and preparation process, it is limited by low strength in practical applications. Therefore, highly porous hydroxyapatite scaffolds reinforced with 0 to 30 wt% doped wollastonite (WS) (HA/WS) were prepared by freeze-drying in combination with pressureless sintering method. The results demonstrated that WS could consistently improve the compressive properties of HA/WS scaffolds. The HA/WS scaffolds have optimal total porosity with good open pores and internal interconnections when the WS doping is 10%. In vitro osteoclast attachment experiments indicated that the HA/WS scaffolds had good biocompatibility. The findings of this study provide theoretical guidance for the application of HA in the field of artificial implants.

KW - bioceramics

KW - biocompatibility

KW - compressive strength

KW - freeze-drying

KW - HA/WS scaffolds

UR - http://www.scopus.com/inward/record.url?scp=85200204391&partnerID=8YFLogxK

U2 - 10.1177/02670836241265073

DO - 10.1177/02670836241265073

M3 - Article

AN - SCOPUS:85200204391

SN - 0267-0836

VL - 41

SP - 627

EP - 634

JO - Materials Science and Technology (United Kingdom)

JF - Materials Science and Technology (United Kingdom)

IS - 9

ER -

Micro-pore structures and compressive strengths of hydroxyapatite/wollastonite scaffolds prepared by freezing dry

Abstract

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