Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

C. A. Kassed, T. L. Butler, M. T. Navidomskis, M. N. Gordon, D. Morgan, K. R. Pennypacker

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalMolecular Brain Research
Volume110
Issue number1
DOIs
Publication statusPublished - 31 Jan 2003
Externally publishedYes

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