Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

C. A. Kassed; T. L. Butler; M. T. Navidomskis; M. N. Gordon; D. Morgan; K. R. Pennypacker

doi:10.1016/S0169-328X(02)00658-7

Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

C. A. Kassed, T. L. Butler, M. T. Navidomskis, M. N. Gordon, D. Morgan, K. R. Pennypacker

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.

Original language	English
Pages (from-to)	152-157
Number of pages	6
Journal	Molecular Brain Research
Volume	110
Issue number	1
DOIs	https://doi.org/10.1016/S0169-328X(02)00658-7
Publication status	Published - 31 Jan 2003
Externally published	Yes

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10.1016/S0169-328X(02)00658-7

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@article{7b899d1e53f440cb9cbbdbcfbfbbb5df,

title = "Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury",

abstract = "Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.",

keywords = "Fluoro-Jade, Hippocampus, mutPS-1 mice, Neurodegeneration, Neuroprotection, Neurotoxicity, NF-κB, P50, Presenilin-1 gene mutations, Resistance to injury, Signal transduction, Transcription factors, Trimethyltin",

author = "Kassed, {C. A.} and Butler, {T. L.} and Navidomskis, {M. T.} and Gordon, {M. N.} and D. Morgan and Pennypacker, {K. R.}",

note = "Funding Information: This research was supported by NIH Grant RO1 NS39141-01A2 and American Heart Association Grants 9930072N (K.R.P.) and 0120233B (T.L.B.). ",

year = "2003",

month = jan,

day = "31",

doi = "10.1016/S0169-328X(02)00658-7",

language = "English",

volume = "110",

pages = "152--157",

journal = "Molecular Brain Research",

issn = "0169-328X",

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number = "1",

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TY - JOUR

T1 - Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

AU - Kassed, C. A.

AU - Butler, T. L.

AU - Navidomskis, M. T.

AU - Gordon, M. N.

AU - Morgan, D.

AU - Pennypacker, K. R.

N1 - Funding Information: This research was supported by NIH Grant RO1 NS39141-01A2 and American Heart Association Grants 9930072N (K.R.P.) and 0120233B (T.L.B.).

PY - 2003/1/31

Y1 - 2003/1/31

N2 - Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.

AB - Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.

KW - Fluoro-Jade

KW - Hippocampus

KW - mutPS-1 mice

KW - Neurodegeneration

KW - Neuroprotection

KW - Neurotoxicity

KW - NF-κB

KW - P50

KW - Presenilin-1 gene mutations

KW - Resistance to injury

KW - Signal transduction

KW - Transcription factors

KW - Trimethyltin

UR - http://www.scopus.com/inward/record.url?scp=0037474096&partnerID=8YFLogxK

U2 - 10.1016/S0169-328X(02)00658-7

DO - 10.1016/S0169-328X(02)00658-7

M3 - Article

C2 - 12573544

AN - SCOPUS:0037474096

SN - 0169-328X

VL - 110

SP - 152

EP - 157

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1

ER -

Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

Abstract

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