Metoclopramide-Induced Raised Intracranial Pressure After Head Injury

S. Deehan, Geoffrey Dobb

    Research output: Contribution to journalReview article

    18 Citations (Scopus)

    Abstract

    We report a case of raised intracranial pressure in a head-injured patient following the intravenous administration of metoclopramide. The patient required admission to an intensive care unit after a road traffic accident. A CT scan of the head was consistent with diffuse axonal injury and supportive management included intracranial pressure monitoring. On the third day after admission, intravenous metoclopramide 10mg was administered to aid gastric emptying during nasogastric feeding. Intracranial pressure increased to 39mmHg from a baseline of 15-20mmHg. The same dose of metoclopramide was repeated the next day during transcranial doppler studies with an increase in ICP to 34mmHg and an associated rise in middle cerebral artery systolic blood velocity from 122cms-1 to 150cms-1. This effect of metoclopramide has not been previously reported.
    Original languageEnglish
    Pages (from-to)157-160
    JournalJournal of Neurosurgical Anesthesiology
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - 2002

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    Metoclopramide
    Intracranial Pressure
    Craniocerebral Trauma
    Diffuse Axonal Injury
    Head
    Traffic Accidents
    Patient Admission
    Gastric Emptying
    Middle Cerebral Artery
    Intravenous Administration
    Intensive Care Units

    Cite this

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    title = "Metoclopramide-Induced Raised Intracranial Pressure After Head Injury",
    abstract = "We report a case of raised intracranial pressure in a head-injured patient following the intravenous administration of metoclopramide. The patient required admission to an intensive care unit after a road traffic accident. A CT scan of the head was consistent with diffuse axonal injury and supportive management included intracranial pressure monitoring. On the third day after admission, intravenous metoclopramide 10mg was administered to aid gastric emptying during nasogastric feeding. Intracranial pressure increased to 39mmHg from a baseline of 15-20mmHg. The same dose of metoclopramide was repeated the next day during transcranial doppler studies with an increase in ICP to 34mmHg and an associated rise in middle cerebral artery systolic blood velocity from 122cms-1 to 150cms-1. This effect of metoclopramide has not been previously reported.",
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    Metoclopramide-Induced Raised Intracranial Pressure After Head Injury. / Deehan, S.; Dobb, Geoffrey.

    In: Journal of Neurosurgical Anesthesiology, Vol. 14, No. 2, 2002, p. 157-160.

    Research output: Contribution to journalReview article

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    T1 - Metoclopramide-Induced Raised Intracranial Pressure After Head Injury

    AU - Deehan, S.

    AU - Dobb, Geoffrey

    PY - 2002

    Y1 - 2002

    N2 - We report a case of raised intracranial pressure in a head-injured patient following the intravenous administration of metoclopramide. The patient required admission to an intensive care unit after a road traffic accident. A CT scan of the head was consistent with diffuse axonal injury and supportive management included intracranial pressure monitoring. On the third day after admission, intravenous metoclopramide 10mg was administered to aid gastric emptying during nasogastric feeding. Intracranial pressure increased to 39mmHg from a baseline of 15-20mmHg. The same dose of metoclopramide was repeated the next day during transcranial doppler studies with an increase in ICP to 34mmHg and an associated rise in middle cerebral artery systolic blood velocity from 122cms-1 to 150cms-1. This effect of metoclopramide has not been previously reported.

    AB - We report a case of raised intracranial pressure in a head-injured patient following the intravenous administration of metoclopramide. The patient required admission to an intensive care unit after a road traffic accident. A CT scan of the head was consistent with diffuse axonal injury and supportive management included intracranial pressure monitoring. On the third day after admission, intravenous metoclopramide 10mg was administered to aid gastric emptying during nasogastric feeding. Intracranial pressure increased to 39mmHg from a baseline of 15-20mmHg. The same dose of metoclopramide was repeated the next day during transcranial doppler studies with an increase in ICP to 34mmHg and an associated rise in middle cerebral artery systolic blood velocity from 122cms-1 to 150cms-1. This effect of metoclopramide has not been previously reported.

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    DO - 10.1097/00008506-200204000-00013

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    JO - Journal of Neurosurgical Anesthesiology

    JF - Journal of Neurosurgical Anesthesiology

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