Projects per year
Abstract
Aim:We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.Materials & methods:We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).Results & conclusion:We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations nearTXNIP,ADCY7,SREBF1andRAP1GAP2that had not previously been associated with obesity-related traits.
Original language | English |
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Pages (from-to) | 1483-1499 |
Number of pages | 17 |
Journal | Epigenomics |
Volume | 12 |
Issue number | 17 |
DOIs | |
Publication status | Published - Sept 2020 |
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Investigating the mechanisms and preventative strategies to alleviate the burden of cardiovascular disease
Mori, T. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/18 → 31/12/22
Project: Research
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Rae-Chi Huang - Early Life Programming of Cardiovascular Disease
Huang, R.-C. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/13 → 29/02/20
Project: Research
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403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort
Beilin, L. (Chief Investigator), Palmer, L. (Chief Investigator), Oddy, W. (Chief Investigator), Mori, T. (Chief Investigator), Kendall, G. (Chief Investigator) & Hands, B. (Chief Investigator)
1/01/06 → 31/12/09
Project: Research