Projects per year
Abstract
Aim:We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.Materials & methods:We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).Results & conclusion:We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations nearTXNIP,ADCY7,SREBF1andRAP1GAP2that had not previously been associated with obesity-related traits.
Original language | English |
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Pages (from-to) | 1483-1499 |
Number of pages | 17 |
Journal | Epigenomics |
Volume | 12 |
Issue number | 17 |
DOIs | |
Publication status | Published - Sept 2020 |
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LIFECYCLE - Early Life Stressors and LifeCycle Health
Huang, R.
National Health & Medical Research Council NHMRC
1/01/17 → 31/08/23
Project: Research
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Rae-Chi Huang - Early Life Programming of Cardiovascular Disease
Huang, R.
National Health & Medical Research Council NHMRC
1/01/13 → 29/02/20
Project: Research