Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

Anne E Justice; Geetha Chittoor; Rahul Gondalia; Phillip E Melton; Elise Lim; Megan L Grove; Eric A Whitsel; Ching-Ti Liu; L Adrienne Cupples; Lindsay Fernandez-Rhodes; Weihua Guan; Jan Bressler; Myriam Fornage; Eric Boerwinkle; Yun Li; Ellen Demerath; Nancy Heard-Costa; Dan Levy; James D Stewart; Andrea Baccarelli; Lifang Hou; Karen Conneely; Trevor A Mori; Lawrence J Beilin; Rae-Chi Huang; Penny Gordon-Larsen; Annie Green Howard; Kari E North

doi:10.2217/epi-2019-0276

Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

Anne E Justice, Geetha Chittoor, Rahul Gondalia, Phillip E Melton, Elise Lim, Megan L Grove, Eric A Whitsel, Ching-Ti Liu, L Adrienne Cupples, Lindsay Fernandez-Rhodes, Weihua Guan, Jan Bressler, Myriam Fornage, Eric Boerwinkle, Yun Li, Ellen Demerath, Nancy Heard-Costa, Dan Levy, James D Stewart, Andrea BaccarelliLifang Hou, Karen Conneely, Trevor A Mori, Lawrence J Beilin, Rae-Chi Huang, Penny Gordon-Larsen, Annie Green Howard, Kari E North

Research output: Contribution to journal › Article › peer-review

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Abstract

Aim:We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.Materials & methods:We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).Results & conclusion:We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations nearTXNIP,ADCY7,SREBF1andRAP1GAP2that had not previously been associated with obesity-related traits.

Original language	English
Pages (from-to)	1483-1499
Number of pages	17
Journal	Epigenomics
Volume	12
Issue number	17
DOIs	https://doi.org/10.2217/epi-2019-0276
Publication status	Published - Sept 2020

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10.2217/epi-2019-0276

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Justice, A. E., Chittoor, G., Gondalia, R., Melton, P. E., Lim, E., Grove, M. L., Whitsel, E. A., Liu, C.-T., Cupples, L. A., Fernandez-Rhodes, L., Guan, W., Bressler, J., Fornage, M., Boerwinkle, E., Li, Y., Demerath, E., Heard-Costa, N., Levy, D., Stewart, J. D., ... North, K. E. (2020). Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems. Epigenomics, 12(17), 1483-1499. https://doi.org/10.2217/epi-2019-0276

@article{070155f6b3d147ce9e3d93b6f1ce2cbf,

title = "Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems",

abstract = "Aim:We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.Materials & methods:We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).Results & conclusion:We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations nearTXNIP,ADCY7,SREBF1andRAP1GAP2that had not previously been associated with obesity-related traits.",

keywords = "ancestrally diverse, body fat distribution, cardiometabolic disease, central adiposity, DNA methylation, methylome-wide association study, TXNIP, waist circumference, waist-to-height ratio, waist-to-hip ratio, BODY-MASS INDEX, GTPASE-ACTIVATING PROTEIN, DNA METHYLATION, EPIGENOME-WIDE, BLOOD-PRESSURE, WAIST CIRCUMFERENCE, PERIPHERAL-BLOOD, EXPRESSION DATA, OBESITY, LOCI",

author = "Justice, {Anne E} and Geetha Chittoor and Rahul Gondalia and Melton, {Phillip E} and Elise Lim and Grove, {Megan L} and Whitsel, {Eric A} and Ching-Ti Liu and Cupples, {L Adrienne} and Lindsay Fernandez-Rhodes and Weihua Guan and Jan Bressler and Myriam Fornage and Eric Boerwinkle and Yun Li and Ellen Demerath and Nancy Heard-Costa and Dan Levy and Stewart, {James D} and Andrea Baccarelli and Lifang Hou and Karen Conneely and Mori, {Trevor A} and Beilin, {Lawrence J} and Rae-Chi Huang and Penny Gordon-Larsen and Howard, {Annie Green} and North, {Kari E}",

year = "2020",

month = sep,

doi = "10.2217/epi-2019-0276",

language = "English",

volume = "12",

pages = "1483--1499",

journal = "Epigenomics",

issn = "1750-1911",

publisher = "Future Medicine Ltd",

number = "17",

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Justice, AE, Chittoor, G, Gondalia, R, Melton, PE, Lim, E, Grove, ML, Whitsel, EA, Liu, C-T, Cupples, LA, Fernandez-Rhodes, L, Guan, W, Bressler, J, Fornage, M, Boerwinkle, E, Li, Y, Demerath, E, Heard-Costa, N, Levy, D, Stewart, JD, Baccarelli, A, Hou, L, Conneely, K, Mori, TA , Beilin, LJ, Huang, R-C, Gordon-Larsen, P, Howard, AG & North, KE 2020, 'Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems', Epigenomics, vol. 12, no. 17, pp. 1483-1499. https://doi.org/10.2217/epi-2019-0276

TY - JOUR

T1 - Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

AU - Justice, Anne E

AU - Chittoor, Geetha

AU - Gondalia, Rahul

AU - Melton, Phillip E

AU - Lim, Elise

AU - Grove, Megan L

AU - Whitsel, Eric A

AU - Liu, Ching-Ti

AU - Cupples, L Adrienne

AU - Fernandez-Rhodes, Lindsay

AU - Guan, Weihua

AU - Bressler, Jan

AU - Fornage, Myriam

AU - Boerwinkle, Eric

AU - Li, Yun

AU - Demerath, Ellen

AU - Heard-Costa, Nancy

AU - Levy, Dan

AU - Stewart, James D

AU - Baccarelli, Andrea

AU - Hou, Lifang

AU - Conneely, Karen

AU - Mori, Trevor A

AU - Beilin, Lawrence J

AU - Huang, Rae-Chi

AU - Gordon-Larsen, Penny

AU - Howard, Annie Green

AU - North, Kari E

PY - 2020/9

Y1 - 2020/9

N2 - Aim:We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.Materials & methods:We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).Results & conclusion:We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations nearTXNIP,ADCY7,SREBF1andRAP1GAP2that had not previously been associated with obesity-related traits.

AB - Aim:We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.Materials & methods:We validated significantly associated cytosine-phosphate-guanine methylation sites (CpGs) among adults using the Women's Health Initiative and Framingham Heart Study participants (combined n = 5743) and generalized associations in adolescents from The Raine Study (n = 820).Results & conclusion:We identified 11 CpGs that were robustly associated with one or more central adiposity trait in adults and two in adolescents, including CpG site associations nearTXNIP,ADCY7,SREBF1andRAP1GAP2that had not previously been associated with obesity-related traits.

KW - ancestrally diverse

KW - body fat distribution

KW - cardiometabolic disease

KW - central adiposity

KW - DNA methylation

KW - methylome-wide association study

KW - TXNIP

KW - waist circumference

KW - waist-to-height ratio

KW - waist-to-hip ratio

KW - BODY-MASS INDEX

KW - GTPASE-ACTIVATING PROTEIN

KW - DNA METHYLATION

KW - EPIGENOME-WIDE

KW - BLOOD-PRESSURE

KW - WAIST CIRCUMFERENCE

KW - PERIPHERAL-BLOOD

KW - EXPRESSION DATA

KW - OBESITY

KW - LOCI

UR - http://www.scopus.com/inward/record.url?scp= 85092120301&partnerID=8YFLogxK

U2 - 10.2217/epi-2019-0276

DO - 10.2217/epi-2019-0276

M3 - Article

C2 - 32901515

SN - 1750-1911

VL - 12

SP - 1483

EP - 1499

JO - Epigenomics

JF - Epigenomics

IS - 17

ER -

Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

Abstract

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Investigating the mechanisms and preventative strategies to alleviate the burden of cardiovascular disease

Rae-Chi Huang - Early Life Programming of Cardiovascular Disease

403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort

Cite this

Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

Investigating the mechanisms and preventative strategies to alleviate the burden of cardiovascular disease

Rae-Chi Huang - Early Life Programming of Cardiovascular Disease

403981: Childhood Precursors of Adult Cardiovascular Disease, Obesity and Diabetes- 16 Year Follow up of a Longitudinal Cohort

Cite this