Methods for determining the redox status of proteins

Richard Lipscombe (Inventor), Peter Arthur (Inventor), James K. C. Lui (Inventor)

Research output: Patentpeer-review

Abstract

A method for determining the redox status of a protein sample, the method comprising the steps of: a) contacting the sample with a first label adapted to bind to at least one reduced cysteine group therein; b) contacting the sample with a reducing agent to reduce at least one oxidized cysteine group therein; c) contacting the sample with a second label adapted to bind to any reduced cysteine groups produced in step (b); and d) determining the ratio of the signal from the first label to the signal from the second label wherein the ratio indicates the redox status.
Original languageEnglish
Patent numberUS-8043824-B2
Publication statusPublished - 22 Nov 2005

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