Methadone distribution and excretion into breast milk of clients in a methadone maintenance programme

R.E. Wojnar-Horton, J.H. Kristensen, P. Yapp, Kenneth Ilett, L.J. Dusci, L.P. Hackett

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Abstract

Aims Methadone is widely used in maintenance programs for opioid-dependent subjects. The aims of the study were to quantify the distribution and excretion of methadone in human milk during the early postnatal period and to investigate exposure of breast fed infants to the drug.Methods Blood and milk samples were obtained from 12 breast feeding women who were taking methadone in daily doses ranging from 20-80 mg (0.3-1.14 mg kg(-1)). Blood was also obtained from eight of their infants. Methadone concentration in these samples was quantified by h.p.l.c. The infants were observed for withdrawal symptoms.Results The mean (95% CI) milk/plasma ratio was 0.44 (0.24-0.64). Exposure of the infants, calculated assuming an average milk intake of 0.15 l kg(-1) day and a bioavailability of 100% was 17.4 (10.8-24) mu g kg(-1) day(-1). The mean infant dose expressed as a percentage of the maternal dose was 2.79 (2.07-3.51)%. Methadone concentrations in seven infants were below the limit of detection for the h.p.l.c. assay procedure, while one infant had a plasma methadone concentration 6.5 mu g l(-1). Infant exposure to methadone via human milk was insufficient to prevent the development of a neonatal abstinence syndrome which was seen in seven (64%) infants. No adverse effects attributable to methadone in milk were seen.Conclusions We conclude that exposure of breast fed infants to methadone taken by their mothers is minimal and that women in methadone maintenance programs should not be discouraged from breast feeding because of this exposure.
Original languageEnglish
Pages (from-to)543-547
JournalBritish Journal of Clinical Pharmacology
Volume44
DOIs
Publication statusPublished - 1997

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