Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening-Current concepts

D. Cadosch; Erwin Chan; O. Gautschi; Luis Filgueira

doi:10.1002/jbm.a.32625

Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening-Current concepts

D. Cadosch, Erwin Chan, O. Gautschi, Luis Filgueira

Research output: Contribution to journal › Literature review

132 Citations (Scopus)

Abstract

Metal implants are essential therapeutic tools for the treatment of bone fractures and joint replacements. The metals and metal alloys used in contemporary orthopedic and trauma surgery are well tolerated by the majority of patients. However, complications resulting from inflammatory and immune reactions to metal implants have been well documented. This review briefly discusses the different mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation. Additionally, this article reviews the effects of the released ions on bone metabolism and the immune system and discusses their involvement in the pathophysiological mechanisms of aseptic loosening and metal hypersensitivity in patients with metal implants. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

Original language	English
Pages (from-to)	1252-1262
Journal	Journal of Biomedical Materials Research Part A
Volume	91A
Issue number	4
DOIs	https://doi.org/10.1002/jbm.a.32625
Publication status	Published - 15 Dec 2009

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title = "Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening-Current concepts",

abstract = "Metal implants are essential therapeutic tools for the treatment of bone fractures and joint replacements. The metals and metal alloys used in contemporary orthopedic and trauma surgery are well tolerated by the majority of patients. However, complications resulting from inflammatory and immune reactions to metal implants have been well documented. This review briefly discusses the different mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation. Additionally, this article reviews the effects of the released ions on bone metabolism and the immune system and discusses their involvement in the pathophysiological mechanisms of aseptic loosening and metal hypersensitivity in patients with metal implants. {\textcopyright} 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009 ",

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AU - Cadosch, D.

AU - Chan, Erwin

AU - Gautschi, O.

AU - Filgueira, Luis

PY - 2009/12/15

Y1 - 2009/12/15

N2 - Metal implants are essential therapeutic tools for the treatment of bone fractures and joint replacements. The metals and metal alloys used in contemporary orthopedic and trauma surgery are well tolerated by the majority of patients. However, complications resulting from inflammatory and immune reactions to metal implants have been well documented. This review briefly discusses the different mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation. Additionally, this article reviews the effects of the released ions on bone metabolism and the immune system and discusses their involvement in the pathophysiological mechanisms of aseptic loosening and metal hypersensitivity in patients with metal implants. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

AB - Metal implants are essential therapeutic tools for the treatment of bone fractures and joint replacements. The metals and metal alloys used in contemporary orthopedic and trauma surgery are well tolerated by the majority of patients. However, complications resulting from inflammatory and immune reactions to metal implants have been well documented. This review briefly discusses the different mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation. Additionally, this article reviews the effects of the released ions on bone metabolism and the immune system and discusses their involvement in the pathophysiological mechanisms of aseptic loosening and metal hypersensitivity in patients with metal implants. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

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JF - Journal of Biomedical Materials Research

SN - 1549-3296

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Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening-Current concepts

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