Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening-Current concepts

D. Cadosch, Erwin Chan, O. Gautschi, Luis Filgueira

    Research output: Contribution to journalLiterature review

    145 Citations (Scopus)

    Abstract

    Metal implants are essential therapeutic tools for the treatment of bone fractures and joint replacements. The metals and metal alloys used in contemporary orthopedic and trauma surgery are well tolerated by the majority of patients. However, complications resulting from inflammatory and immune reactions to metal implants have been well documented. This review briefly discusses the different mechanisms of metal implant corrosion in the human body, which lead to the release of significant levels of metal ions into the peri-implant tissues and the systemic blood circulation. Additionally, this article reviews the effects of the released ions on bone metabolism and the immune system and discusses their involvement in the pathophysiological mechanisms of aseptic loosening and metal hypersensitivity in patients with metal implants. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
    Original languageEnglish
    Pages (from-to)1252-1262
    JournalJournal of Biomedical Materials Research Part A
    Volume91A
    Issue number4
    DOIs
    Publication statusPublished - 15 Dec 2009

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