Metagenomic studies of disease vectors: a tool for microbial surveillance and discovery

Simon Williams

Research output: ThesisDoctoral Thesis

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Abstract

Vector-borne infectious diseases pose a persistent challenge to human health. Here, we provide the first description of the faecal virome, bacteriome, and resistome of house mice in New York City. Using high-throughput molecular approaches, we detected broad viral diversity, potentially pathogenic bacteria, and antimicrobial resistance determinants. We also assessed Culex annulirostris mosquitoes trapped in Western Australia and identified sixteen divergent viruses, virome heterogeneity and an uneven viral distribution. Finally, we present a characterzation of two viruses identified in mosquitoes: Fitzroy River virus, a potentially pathogenic flavivirus and Jogalong virus, a hepacivirus likely associated with birds.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Lipkin, Walter Ian, Supervisor, External person
  • Imrie, Allison, Supervisor
  • Smith, David, Supervisor
  • Johansen, Cheryl, Supervisor
Award date28 May 2020
DOIs
Publication statusUnpublished - 2020

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