Metabolites of Lactose Synthesis in Milk from Diabetic and Nondiabetic Women During Lactogenesis II

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Abstract

The concentrations of lactose, glucose, glucose 6-phosphate (G6P), glucose 1-phosphate (GIP), UDPglucose (UDPglc), UDPgalactose (UDPgal), and inorganic phosphate (P(i)) (metabolites in the lactose synthesis pathway) were measured in mammary secretion from nondiabetic (ND) and insulin-dependent diabetic (IDD) mothers during the first 10 days postpartum to determine their relationship with the amount of lactose synthesized and their association with the delay in lactose synthesis in IDD mothers. For all mothers the concentrations of all metabolites were low initially, and in ND mothers the first increases occurred as follows: lactose-day 2; glucose, G6P and P(i)-day 3; GIP and UDPglc-day 4; and UDPgal-day 6. The first increases for IDD mothers occurred 1-4 days later than for ND mothers. The concentrations of glucose, G6P, G1P, UDPglc, and P(i) were related to the amount of lactose synthesized. Since the rate of lactose synthesis and concentrations of other metabolites were less than half-maximal while the concentration of glucose was low, and since there was a delay in the increase in mammary gland concentrations of glucose in IDD mothers, it is concluded that glucose availability has the potential to play a role in the regulation of the rate of lactose synthesis at lactogenesis II.
Original languageEnglish
Pages (from-to)100-108
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume19
DOIs
Publication statusPublished - 1994

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Lactose
Milk
Mothers
Glucose
Glucose-6-Phosphate
Insulin
Human Mammary Glands
Postpartum Period
Breast
Phosphates

Cite this

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title = "Metabolites of Lactose Synthesis in Milk from Diabetic and Nondiabetic Women During Lactogenesis II",
abstract = "The concentrations of lactose, glucose, glucose 6-phosphate (G6P), glucose 1-phosphate (GIP), UDPglucose (UDPglc), UDPgalactose (UDPgal), and inorganic phosphate (P(i)) (metabolites in the lactose synthesis pathway) were measured in mammary secretion from nondiabetic (ND) and insulin-dependent diabetic (IDD) mothers during the first 10 days postpartum to determine their relationship with the amount of lactose synthesized and their association with the delay in lactose synthesis in IDD mothers. For all mothers the concentrations of all metabolites were low initially, and in ND mothers the first increases occurred as follows: lactose-day 2; glucose, G6P and P(i)-day 3; GIP and UDPglc-day 4; and UDPgal-day 6. The first increases for IDD mothers occurred 1-4 days later than for ND mothers. The concentrations of glucose, G6P, G1P, UDPglc, and P(i) were related to the amount of lactose synthesized. Since the rate of lactose synthesis and concentrations of other metabolites were less than half-maximal while the concentration of glucose was low, and since there was a delay in the increase in mammary gland concentrations of glucose in IDD mothers, it is concluded that glucose availability has the potential to play a role in the regulation of the rate of lactose synthesis at lactogenesis II.",
author = "Peter Arthur and J.C. Kent and Peter Hartmann",
year = "1994",
doi = "10.1097/00005176-199407000-00017",
language = "English",
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pages = "100--108",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
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publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - Metabolites of Lactose Synthesis in Milk from Diabetic and Nondiabetic Women During Lactogenesis II

AU - Arthur, Peter

AU - Kent, J.C.

AU - Hartmann, Peter

PY - 1994

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N2 - The concentrations of lactose, glucose, glucose 6-phosphate (G6P), glucose 1-phosphate (GIP), UDPglucose (UDPglc), UDPgalactose (UDPgal), and inorganic phosphate (P(i)) (metabolites in the lactose synthesis pathway) were measured in mammary secretion from nondiabetic (ND) and insulin-dependent diabetic (IDD) mothers during the first 10 days postpartum to determine their relationship with the amount of lactose synthesized and their association with the delay in lactose synthesis in IDD mothers. For all mothers the concentrations of all metabolites were low initially, and in ND mothers the first increases occurred as follows: lactose-day 2; glucose, G6P and P(i)-day 3; GIP and UDPglc-day 4; and UDPgal-day 6. The first increases for IDD mothers occurred 1-4 days later than for ND mothers. The concentrations of glucose, G6P, G1P, UDPglc, and P(i) were related to the amount of lactose synthesized. Since the rate of lactose synthesis and concentrations of other metabolites were less than half-maximal while the concentration of glucose was low, and since there was a delay in the increase in mammary gland concentrations of glucose in IDD mothers, it is concluded that glucose availability has the potential to play a role in the regulation of the rate of lactose synthesis at lactogenesis II.

AB - The concentrations of lactose, glucose, glucose 6-phosphate (G6P), glucose 1-phosphate (GIP), UDPglucose (UDPglc), UDPgalactose (UDPgal), and inorganic phosphate (P(i)) (metabolites in the lactose synthesis pathway) were measured in mammary secretion from nondiabetic (ND) and insulin-dependent diabetic (IDD) mothers during the first 10 days postpartum to determine their relationship with the amount of lactose synthesized and their association with the delay in lactose synthesis in IDD mothers. For all mothers the concentrations of all metabolites were low initially, and in ND mothers the first increases occurred as follows: lactose-day 2; glucose, G6P and P(i)-day 3; GIP and UDPglc-day 4; and UDPgal-day 6. The first increases for IDD mothers occurred 1-4 days later than for ND mothers. The concentrations of glucose, G6P, G1P, UDPglc, and P(i) were related to the amount of lactose synthesized. Since the rate of lactose synthesis and concentrations of other metabolites were less than half-maximal while the concentration of glucose was low, and since there was a delay in the increase in mammary gland concentrations of glucose in IDD mothers, it is concluded that glucose availability has the potential to play a role in the regulation of the rate of lactose synthesis at lactogenesis II.

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M3 - Article

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SN - 0277-2116

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