@phdthesis{2636ebdd6b6c4b7295dcba48d7cb8adc,
title = "Metabolic, Vascular and Therapeutic Aspects of Lipoprotein(a)",
abstract = "Lipoprotein(a) [Lp(a)] is a causal risk factor of atherosclerotic cardiovascular disease (ASCVD). Clinical interventions using proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors or high dose omega-3 fatty acids (ω-3FAs) may have an impact on Lp(a) metabolism and associated cardiovascular sequelae. Five studies were carried out to investigate the metabolic, vascular and therapeutic aspects of Lp(a). The results of these studies collectively support the overall hypothesis of the thesis that the metabolism of Lp(a) and associated cardiovascular sequelae are modifiable by clinical interventions in human subjects.",
keywords = "Lipoprotein(a), familial hypercholesterolaemia, PCSK9 inhibitor, omega-3 fatty acids, clinical interventions",
author = "Qidi Ying",
year = "2023",
doi = "10.26182/pv1j-zh63",
language = "English",
school = "The University of Western Australia",
}