Metabolic, respiratory and haematological adjustments of the little pocket mouse to circadian torpor cycles

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Abstract

Metabolic, respiratory and haematological parameters were investigated for the Little Pocket mouse during circadian torpor cycles. The rate of O2, consumption decreased from 7.04 to 0.05 ml O2· g-1· hr-1, with a corresponding decrease in respiratory minute volume from 49.4 to 0.9 ml · min-1 during torpor at an ambient temperature of 10 C. No changes in haemoglobin concentration (19.7 g/100 ml), haematocrit (54 %), red blood corpuscle count (12.4 106/μl), mean corpuscular volume (43.6 μm3), mean corpuscular haemoglobin content (16.2 pg), mean corpuscular haemoglobin concentration (37.4 %) and [2,3-DPG] (9.6 μmol/g Hb) were observed during torpor cycles. The half saturation tension of P. longimembris haemoglobin was 41 mm Hg (37 C, pH = 7.28) and 19.7 mmHg (10 C, pH = 7.51).The effect of temperature on P50was Δlog P50/ C = + 0.0106(pH = 7.4). Venous blood parameters were: euthermic mice (37 C); PCO2 = 36.8 mm Hg, PO2 = 49.5 mm Hg, pH = 7.28,[HCO3-] = 17.3mmol/l ; torpid mice (10 C) ; PCO2 = 14.6,PO2 = 35.7,pH = 7.51,[HCC3] = 18.8. These data indicate a new, relatively acidotic acid-base status during torpor, characterised by a higher H+/OH- ratio. The respiratory sensitivity to inspired CO2 of pocket mice was, despite their being semi-fossorial, typical of other mammals. High concentrations of CO2, did not induce, or facilitate, entry into torpor. © 1977.
Original languageEnglish
Pages (from-to)295-307
Number of pages13
JournalRespiration Physiology
Volume31
Issue number3
DOIs
Publication statusPublished - 1977

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Torpor
Erythrocyte Indices
Hemoglobins
2,3-Diphosphoglycerate
Temperature
Hematocrit
Mammals
Erythrocytes
Acids

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@article{60d717a0332f4ee8af9c3ff3c242b453,
title = "Metabolic, respiratory and haematological adjustments of the little pocket mouse to circadian torpor cycles",
abstract = "Metabolic, respiratory and haematological parameters were investigated for the Little Pocket mouse during circadian torpor cycles. The rate of O2, consumption decreased from 7.04 to 0.05 ml O2· g-1· hr-1, with a corresponding decrease in respiratory minute volume from 49.4 to 0.9 ml · min-1 during torpor at an ambient temperature of 10 C. No changes in haemoglobin concentration (19.7 g/100 ml), haematocrit (54 {\%}), red blood corpuscle count (12.4 106/μl), mean corpuscular volume (43.6 μm3), mean corpuscular haemoglobin content (16.2 pg), mean corpuscular haemoglobin concentration (37.4 {\%}) and [2,3-DPG] (9.6 μmol/g Hb) were observed during torpor cycles. The half saturation tension of P. longimembris haemoglobin was 41 mm Hg (37 C, pH = 7.28) and 19.7 mmHg (10 C, pH = 7.51).The effect of temperature on P50was Δlog P50/ C = + 0.0106(pH = 7.4). Venous blood parameters were: euthermic mice (37 C); PCO2 = 36.8 mm Hg, PO2 = 49.5 mm Hg, pH = 7.28,[HCO3-] = 17.3mmol/l ; torpid mice (10 C) ; PCO2 = 14.6,PO2 = 35.7,pH = 7.51,[HCC3] = 18.8. These data indicate a new, relatively acidotic acid-base status during torpor, characterised by a higher H+/OH- ratio. The respiratory sensitivity to inspired CO2 of pocket mice was, despite their being semi-fossorial, typical of other mammals. High concentrations of CO2, did not induce, or facilitate, entry into torpor. {\circledC} 1977.",
keywords = "Acid-base balance Body temperature Heterotherm Oxygen affinity Oxygen consumption Ventilation",
author = "Withers, {P. C.}",
year = "1977",
doi = "10.1016/0034-5687(77)90073-1",
language = "English",
volume = "31",
pages = "295--307",
journal = "Respiration Physiology",
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TY - JOUR

T1 - Metabolic, respiratory and haematological adjustments of the little pocket mouse to circadian torpor cycles

AU - Withers, P. C.

PY - 1977

Y1 - 1977

N2 - Metabolic, respiratory and haematological parameters were investigated for the Little Pocket mouse during circadian torpor cycles. The rate of O2, consumption decreased from 7.04 to 0.05 ml O2· g-1· hr-1, with a corresponding decrease in respiratory minute volume from 49.4 to 0.9 ml · min-1 during torpor at an ambient temperature of 10 C. No changes in haemoglobin concentration (19.7 g/100 ml), haematocrit (54 %), red blood corpuscle count (12.4 106/μl), mean corpuscular volume (43.6 μm3), mean corpuscular haemoglobin content (16.2 pg), mean corpuscular haemoglobin concentration (37.4 %) and [2,3-DPG] (9.6 μmol/g Hb) were observed during torpor cycles. The half saturation tension of P. longimembris haemoglobin was 41 mm Hg (37 C, pH = 7.28) and 19.7 mmHg (10 C, pH = 7.51).The effect of temperature on P50was Δlog P50/ C = + 0.0106(pH = 7.4). Venous blood parameters were: euthermic mice (37 C); PCO2 = 36.8 mm Hg, PO2 = 49.5 mm Hg, pH = 7.28,[HCO3-] = 17.3mmol/l ; torpid mice (10 C) ; PCO2 = 14.6,PO2 = 35.7,pH = 7.51,[HCC3] = 18.8. These data indicate a new, relatively acidotic acid-base status during torpor, characterised by a higher H+/OH- ratio. The respiratory sensitivity to inspired CO2 of pocket mice was, despite their being semi-fossorial, typical of other mammals. High concentrations of CO2, did not induce, or facilitate, entry into torpor. © 1977.

AB - Metabolic, respiratory and haematological parameters were investigated for the Little Pocket mouse during circadian torpor cycles. The rate of O2, consumption decreased from 7.04 to 0.05 ml O2· g-1· hr-1, with a corresponding decrease in respiratory minute volume from 49.4 to 0.9 ml · min-1 during torpor at an ambient temperature of 10 C. No changes in haemoglobin concentration (19.7 g/100 ml), haematocrit (54 %), red blood corpuscle count (12.4 106/μl), mean corpuscular volume (43.6 μm3), mean corpuscular haemoglobin content (16.2 pg), mean corpuscular haemoglobin concentration (37.4 %) and [2,3-DPG] (9.6 μmol/g Hb) were observed during torpor cycles. The half saturation tension of P. longimembris haemoglobin was 41 mm Hg (37 C, pH = 7.28) and 19.7 mmHg (10 C, pH = 7.51).The effect of temperature on P50was Δlog P50/ C = + 0.0106(pH = 7.4). Venous blood parameters were: euthermic mice (37 C); PCO2 = 36.8 mm Hg, PO2 = 49.5 mm Hg, pH = 7.28,[HCO3-] = 17.3mmol/l ; torpid mice (10 C) ; PCO2 = 14.6,PO2 = 35.7,pH = 7.51,[HCC3] = 18.8. These data indicate a new, relatively acidotic acid-base status during torpor, characterised by a higher H+/OH- ratio. The respiratory sensitivity to inspired CO2 of pocket mice was, despite their being semi-fossorial, typical of other mammals. High concentrations of CO2, did not induce, or facilitate, entry into torpor. © 1977.

KW - Acid-base balance Body temperature Heterotherm Oxygen affinity Oxygen consumption Ventilation

U2 - 10.1016/0034-5687(77)90073-1

DO - 10.1016/0034-5687(77)90073-1

M3 - Article

VL - 31

SP - 295

EP - 307

JO - Respiration Physiology

JF - Respiration Physiology

SN - 0034-5687

IS - 3

ER -