@article{38e22f3932a241fcad20d82ddfc450d7,
title = "Metabolic phenotyping of BMI to characterize cardiometabolic risk: evidence from large population-based cohorts",
abstract = "Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with metabolic disorders giving rise to the concept of “metabolically healthy obese”. We use lipidomic-based models for BMI to calculate a metabolic BMI score (mBMI) as a measure of metabolic dysregulation associated with obesity. Using the difference between mBMI and BMI (mBMIΔ), we identify individuals with a similar BMI but differing in their metabolic health and disease risk profiles. Exercise and diet associate with mBMIΔ suggesting the ability to modify mBMI with lifestyle intervention. Our findings show that, the mBMI score captures information on metabolic dysregulation that is independent of the measured BMI and so provides an opportunity to assess metabolic health to identify “at risk” individuals for targeted intervention and monitoring.",
author = "Beyene, {Habtamu B.} and Corey Giles and Kevin Huynh and Tingting Wang and Michelle Cinel and Mellett, {Natalie A.} and Gavriel Olshansky and Meikle, {Thomas G.} and Watts, {Gerald F.} and Joseph Hung and Jennie Hui and Gemma Cadby and John Beilby and John Blangero and Moses, {Eric K.} and Shaw, {Jonathan E.} and Magliano, {Dianna J.} and Meikle, {Peter J.}",
note = "Funding Information: This research was supported by the National Health and Medical Research Council of Australia (Project grant APP1101320 to JES, DJM and PJM). This work was also supported in part by the Victorian Government{\textquoteright}s Operational Infrastructure Support Program. The AusDiab study, initiated and coordinated by the International Diabetes Institute, and subsequently coordinated by the Baker Heart and Diabetes Institute, gratefully acknowledges the support and assistance given by: A Allman, B Atkins, S Bennett, A Bonney, S Chadban, M de Courten, M Dalton, D Dunstan, T Dwyer, H Jahangir, D Jolley, D McCarty, A Meehan, N Meinig, S Murray, K O{\textquoteright}Dea, K Polkinghorne, P Phillips, C Reid, A Stewart, R Tapp, H Taylor, T Welborn, T Whalen, F Wilson, P Zimmet and all the study participants. Also, for funding or logistical support, we are grateful to: National Health and Medical Research Council (NHMRC grant 233200), Australian Government Department of Health and Ageing. Abbott Australasia Pty Ltd, Alphapharm Pty Ltd, AstraZeneca, Bristol-Myers Squibb, City Health Centre-Diabetes Service-Canberra, Department of Health and Community Services—Northern Territory, Department of Health and Human Services—Tasmania, Department of Health—New South Wales, Department of Health – Western Australia, Department of Health—South Australia, Department of Human Services—Victoria, Diabetes Australia, Diabetes Australia Northern Territory, Eli Lilly Australia, Estate of the Late Edward Wilson, GlaxoSmithKline, Jack Brockhoff Foundation, Janssen-Cilag,, Kidney Health Australia, Marian & FH Flack Trust, Menzies Research Institute, Merck Sharp & Dohme, Novartis Pharmaceuticals, Novo Nordisk Pharmaceuticals, Pfizer Pty Ltd, Pratt Foundation, Queensland Health, Roche Diagnostics Australia, Royal Prince Alfred Hospital, Sydney, Sanofi Aventis, sanofi-synthelabo, and the Victorian Government{\textquoteright}s OIS Program. JES, DJM and PJM are supported by Investigator grants from the National Health and Medical Research Council of Australia. HBB was supported by the Baker institute and Monash University Scholarships. The authors wish to thank the staff at the Western Australian Data Linkage Branch and Death Registrations and Hospital Morbidity Data Collection for the provision of linked health data for the BHS. The 1994/95 BHS was supported by a grant from the Health Promotion Foundation of Western Australia, and the authors acknowledge the generous support for the 1994/1995 BHS follow-up from Western Australia and the Great Wine Estates of the Margaret River region of Western Australia. Support from the Royal Perth Hospital Medical Research Foundation is also gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",
year = "2023",
month = dec,
doi = "10.1038/s41467-023-41963-7",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "1",
}
