TY - JOUR
T1 - Metabolic engineering for the production of natural products
AU - Pickens, L.B.
AU - Tang, Y.
AU - Chooi, Heng
PY - 2011
Y1 - 2011
N2 - Natural products and their derivatives play an important role in modern healthcare as frontline treatments for many diseases and as inspiration for chemically synthesized therapeutics. With advances in sequencing and recombinant DNA technology, many of the biosynthetic pathways responsible for the production of these chemically complex yet valuable compounds have been elucidated. With an ever-expanding toolkit of biosynthetic components, metabolic engineering is an increasingly powerful method to improve natural product titers and generate novel compounds. Heterologous production platforms have enabled access to pathways from difficult to culture strains, systems biology and metabolic modeling tools have resulted in increasing predictive and analytic capabilities, advances in expression systems and regulation have enabled the fine-tuning of pathways for increased efficiency, and characterization of individual pathway components has facilitated the construction of hybrid pathways for the production of new compounds. These advances in the many aspects of metabolic engineering not only have yielded fascinating scientific discoveries but also make it an increasingly viable approach for the optimization of natural product biosynthesis. © Copyright 2011 by Annual Reviews. All rights reserved.
AB - Natural products and their derivatives play an important role in modern healthcare as frontline treatments for many diseases and as inspiration for chemically synthesized therapeutics. With advances in sequencing and recombinant DNA technology, many of the biosynthetic pathways responsible for the production of these chemically complex yet valuable compounds have been elucidated. With an ever-expanding toolkit of biosynthetic components, metabolic engineering is an increasingly powerful method to improve natural product titers and generate novel compounds. Heterologous production platforms have enabled access to pathways from difficult to culture strains, systems biology and metabolic modeling tools have resulted in increasing predictive and analytic capabilities, advances in expression systems and regulation have enabled the fine-tuning of pathways for increased efficiency, and characterization of individual pathway components has facilitated the construction of hybrid pathways for the production of new compounds. These advances in the many aspects of metabolic engineering not only have yielded fascinating scientific discoveries but also make it an increasingly viable approach for the optimization of natural product biosynthesis. © Copyright 2011 by Annual Reviews. All rights reserved.
UR - https://www.scopus.com/pages/publications/79959424209
U2 - 10.1146/annurev-chembioeng-061010-114209
DO - 10.1146/annurev-chembioeng-061010-114209
M3 - Article
C2 - 22432617
SN - 1947-5438
VL - 2
SP - 211
EP - 236
JO - Annual Review of Chemical and Biomolecular Engineering
JF - Annual Review of Chemical and Biomolecular Engineering
ER -