Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche

J.R.B. Perry, L. Stolk, N. Franceschini, K.L. Lunetta, G. Zhai, P.F. Mcardle, A.V. Smith, T. Aspelund, S. Bandinelli, E. Boerwinkle, L. Cherkas, G. Eiriksdottir, K. Estranda, L. Ferrucci, A.R. Folsom, M. Garcia, V. Gudnason, A. Hofman, D. Karasik, D.P. Kiel & 19 others L.J. Launer, J. Van Meurs, M.A. Nalls, F. Fivadeneira, A.R. Shuldiner, A. Singleton, N. Soranzo, T. Tanaka, J.A. Visser, M.N. Weedon, Scott Wilson, V. Zhuang, E.A. Streeten, T.B. Harris, A. Murray, T.D. Spector, E.W. Demerath, A.G. Uitterlinden, J.M. Murabito

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10^sup -9^), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10^sup -9^), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation. [PUBLICATION ABSTRACT]
Original languageEnglish
Pages (from-to)648-650
JournalNature Genetics
Volume41
Issue number6
DOIs
Publication statusPublished - 2009

Fingerprint

Menarche
Meta-Analysis
Genome
Genes
Sexual Maturation

Cite this

Perry, J. R. B., Stolk, L., Franceschini, N., Lunetta, K. L., Zhai, G., Mcardle, P. F., ... Murabito, J. M. (2009). Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche. Nature Genetics, 41(6), 648-650. https://doi.org/10.1038/ng.386
Perry, J.R.B. ; Stolk, L. ; Franceschini, N. ; Lunetta, K.L. ; Zhai, G. ; Mcardle, P.F. ; Smith, A.V. ; Aspelund, T. ; Bandinelli, S. ; Boerwinkle, E. ; Cherkas, L. ; Eiriksdottir, G. ; Estranda, K. ; Ferrucci, L. ; Folsom, A.R. ; Garcia, M. ; Gudnason, V. ; Hofman, A. ; Karasik, D. ; Kiel, D.P. ; Launer, L.J. ; Van Meurs, J. ; Nalls, M.A. ; Fivadeneira, F. ; Shuldiner, A.R. ; Singleton, A. ; Soranzo, N. ; Tanaka, T. ; Visser, J.A. ; Weedon, M.N. ; Wilson, Scott ; Zhuang, V. ; Streeten, E.A. ; Harris, T.B. ; Murray, A. ; Spector, T.D. ; Demerath, E.W. ; Uitterlinden, A.G. ; Murabito, J.M. / Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche. In: Nature Genetics. 2009 ; Vol. 41, No. 6. pp. 648-650.
@article{01e0d8ea592f493fb619c33d0d33c825,
title = "Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche",
abstract = "We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10^sup -9^), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10^sup -9^), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation. [PUBLICATION ABSTRACT]",
author = "J.R.B. Perry and L. Stolk and N. Franceschini and K.L. Lunetta and G. Zhai and P.F. Mcardle and A.V. Smith and T. Aspelund and S. Bandinelli and E. Boerwinkle and L. Cherkas and G. Eiriksdottir and K. Estranda and L. Ferrucci and A.R. Folsom and M. Garcia and V. Gudnason and A. Hofman and D. Karasik and D.P. Kiel and L.J. Launer and {Van Meurs}, J. and M.A. Nalls and F. Fivadeneira and A.R. Shuldiner and A. Singleton and N. Soranzo and T. Tanaka and J.A. Visser and M.N. Weedon and Scott Wilson and V. Zhuang and E.A. Streeten and T.B. Harris and A. Murray and T.D. Spector and E.W. Demerath and A.G. Uitterlinden and J.M. Murabito",
year = "2009",
doi = "10.1038/ng.386",
language = "English",
volume = "41",
pages = "648--650",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "6",

}

Perry, JRB, Stolk, L, Franceschini, N, Lunetta, KL, Zhai, G, Mcardle, PF, Smith, AV, Aspelund, T, Bandinelli, S, Boerwinkle, E, Cherkas, L, Eiriksdottir, G, Estranda, K, Ferrucci, L, Folsom, AR, Garcia, M, Gudnason, V, Hofman, A, Karasik, D, Kiel, DP, Launer, LJ, Van Meurs, J, Nalls, MA, Fivadeneira, F, Shuldiner, AR, Singleton, A, Soranzo, N, Tanaka, T, Visser, JA, Weedon, MN, Wilson, S, Zhuang, V, Streeten, EA, Harris, TB, Murray, A, Spector, TD, Demerath, EW, Uitterlinden, AG & Murabito, JM 2009, 'Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche' Nature Genetics, vol. 41, no. 6, pp. 648-650. https://doi.org/10.1038/ng.386

Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche. / Perry, J.R.B.; Stolk, L.; Franceschini, N.; Lunetta, K.L.; Zhai, G.; Mcardle, P.F.; Smith, A.V.; Aspelund, T.; Bandinelli, S.; Boerwinkle, E.; Cherkas, L.; Eiriksdottir, G.; Estranda, K.; Ferrucci, L.; Folsom, A.R.; Garcia, M.; Gudnason, V.; Hofman, A.; Karasik, D.; Kiel, D.P.; Launer, L.J.; Van Meurs, J.; Nalls, M.A.; Fivadeneira, F.; Shuldiner, A.R.; Singleton, A.; Soranzo, N.; Tanaka, T.; Visser, J.A.; Weedon, M.N.; Wilson, Scott; Zhuang, V.; Streeten, E.A.; Harris, T.B.; Murray, A.; Spector, T.D.; Demerath, E.W.; Uitterlinden, A.G.; Murabito, J.M.

In: Nature Genetics, Vol. 41, No. 6, 2009, p. 648-650.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche

AU - Perry, J.R.B.

AU - Stolk, L.

AU - Franceschini, N.

AU - Lunetta, K.L.

AU - Zhai, G.

AU - Mcardle, P.F.

AU - Smith, A.V.

AU - Aspelund, T.

AU - Bandinelli, S.

AU - Boerwinkle, E.

AU - Cherkas, L.

AU - Eiriksdottir, G.

AU - Estranda, K.

AU - Ferrucci, L.

AU - Folsom, A.R.

AU - Garcia, M.

AU - Gudnason, V.

AU - Hofman, A.

AU - Karasik, D.

AU - Kiel, D.P.

AU - Launer, L.J.

AU - Van Meurs, J.

AU - Nalls, M.A.

AU - Fivadeneira, F.

AU - Shuldiner, A.R.

AU - Singleton, A.

AU - Soranzo, N.

AU - Tanaka, T.

AU - Visser, J.A.

AU - Weedon, M.N.

AU - Wilson, Scott

AU - Zhuang, V.

AU - Streeten, E.A.

AU - Harris, T.B.

AU - Murray, A.

AU - Spector, T.D.

AU - Demerath, E.W.

AU - Uitterlinden, A.G.

AU - Murabito, J.M.

PY - 2009

Y1 - 2009

N2 - We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10^sup -9^), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10^sup -9^), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation. [PUBLICATION ABSTRACT]

AB - We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P = 1.7 × 10^sup -9^), where the nearest genes include TMEM38B, FKTN, FSD1L, TAL2 and ZNF462. The next best signal was near the LIN28B gene (rs7759938; P = 7.0 × 10^sup -9^), which also influences adult height. We provide the first evidence for common genetic variants influencing female sexual maturation. [PUBLICATION ABSTRACT]

U2 - 10.1038/ng.386

DO - 10.1038/ng.386

M3 - Article

VL - 41

SP - 648

EP - 650

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 6

ER -

Perry JRB, Stolk L, Franceschini N, Lunetta KL, Zhai G, Mcardle PF et al. Meta-analysis of genome-wide association data identifies two loci kinfluencing age at menarche. Nature Genetics. 2009;41(6):648-650. https://doi.org/10.1038/ng.386