Meta-analysis of gene-level associations for rare variants based on single-variant statistics

Y.-J. Hu, S.I. Berndt, S. Gustafsson, A. Ganna, R. Magi, E. Wheeler, M.F. Feitosa, A.E. Justice, K.L. Monda, D.C. Croteau-Chonka, F.R. Day, T. Esko, T. Fall, T. Ferreira, D. Gentilini, A.U. Jackson, J. Luan, J.C. Randall, S. Vedantam, C.J. WillerT.W. Winkler, A.R. Wood, T. Workalemahu, Y-J. Hu, S.H. Lee, L. Liang, D-Y. Lin, J.L. Min, B.M. Neale, G. Thorleifsson, J. Yang, E. Albrecht, N. Amin, J.L. Bragg-Gresham, Gemma Cadby, M. Den Heijer, N. Eklund, K. Fischer, A. Goel, J-J. Hottenga, J.E. Huffman, I. Jarick, A. Johansson, T. Johnson, S. Kanoni, M.E. Kleber, I.R. Konig, K. Kristiansson, Z. Kutalik, C. Lamina, C. Lecoeur, G. Li, M. Mangino, W.L. Mcardle, C. Medina-Gomez, M. Nuller-Nurasyid, J.S. Ngwa, I.M. Nolte, L. Paternoster, S. Pechlivanis, M. Perola, M.J. Peters, M. Preuss, L.M. Rose, J. Shi, D. Shungin, A.V. Smith, R.J. Strawbridge, I. Surakka, A. Teumer, M.D. Trip, J. Tyrer, J.V. Van Vliet-Ostaptchouk, L. Vandenput, L.L. Waite, J.H. Zhao, D. Absher, F.W. Asselbergs, M. Atalay, A.P. Attwood, A.J. Balmforth, H. Basart, John Beilby, L.L. Bonnycastle, P. Brambilla, M. Bruinenberg, H. Campbell, D.I. Chasman, P.S. Chines, F.S. Collins, J.M. Connell, W. Cookson, U. De Faire, F. De Vegt, M. Dei, M. Dimitriou, S. Edkins, K. Estrada, D.M. Evans, M. Farrall, M.M. Ferrario, J. Ferrieres, L. Franke, F. Frau, P.V. Gejman, H. Grallert, H. Gronberg, V. Gudnason, A.S. Hall, P. Hall, A-L. Hartikainen, C. Hayward, N.L. Heard-Costa, A.C. Heath, J. Hebebrand, G. Homuth, F.B. Hu, S.E. Hunt, E. Hypponen, C. Iribarren, K.B. Jacobs, J-O. Jansson, A. Jula, M. Kahonen, S. Kathiresan, F. Kee, K-T. Khaw, M. Kivimaki, W. Koenig, A.T. Kraja, M. Kumari, K. Kuulasmaa, J. Kuusisto, J.H. Laitinen, T.A. Lakka, C. Langenberg, L.J. Launer, L. Lind, J. Lindstrom, J. Liu, A. Liuzzi, M-L. Lokki, M. Lorentzon, P.A. Madden, P.K. Magnusson, P. Manunta, D. Marek, W. Marz, I.M. Leach, B. Mcknight, S.E. Medland, E. Mihailov, L. Milani, G.W. Montgomery, V. Mooser, T.W. Muhleisen, P.B. Munroe, Arthur Musk, N. Narisu, G. Navis, G. Nicholson, E.A. Nohr, K.K. Ong, B.A. Oostra, C.N.A. Palmer, A. Palotie, J.F. Peden, N. Pedersen, A. Peters, O. Polasek, A. Pouta, P.P Pramstaller, I. Prokopenko, C. Putter, A. Radhakrishnan, O. Raitakari, A. Rendon, F. Rivadeneira, I. Rudan, T.E. Saaristo, J.G. Sambrook, A.R. Sanders, S. Sanna, J. Saramies, S. Schipf, S. Schreiber, H. Schunkert, S-Y. Shin, S. Signorini, J. Sinisalo, B. Skrobek, N. Soranzo, A. Stancakova, K. Stark, J.C. Stephens, K. Stirrups, R.P. Stolk, M. Stumvoll, A.J. Swift, E.V. Theodoraki, B. Thorand, D-A. Tregouet, E. Tremoli, M.M. Van Der Klauw, J.B.J. Van Meurs, S.H. Vermeulen, J. Viikari, J. Virtamo, V. Vitart, G. Waeber, Z. Wang, E. Widen, S.H. Wild, G. Willemsen, B.R. Winkelmann, J.C.M. Witteman, B.H.R. Wolffenbuttel, A. Wong, A.F. Wright, M.C. Zillikens, P. Amouyel, B.O. Boehm, E. Boerwinkle, D.I. Boomsma, M.J. Caulfield, S.J. Chanock, L.A. Cupples, D. Cusi, G.V. Dedoussis, J. Erdmann, J.G. Eriksson, P.W. Franks, P. Froguel, C. Gieger, U. Gyllensten, A. Hamsten, T.B. Harris, C. Hengstenberg, A.A. Hicks, A. Hingorani, A. Hinney, A. Hofman, K.G. Hovingh, K. Hveem, T. Illig, M-R. Jarvelin, K-H. Jockel, S.M. Keinanen-Kiukaanniemi, L.A. Kiemeney, D. Kuh, M. Laakso, T. Lehtimaki, D.F. Levinson, N.G. Martin, A. Metspalu, A.D. Morris, M.S. Nieminen, I. Njolstad, C. Ohlsson, A.J. Oldehinkel, W.H. Ouwehand, Lyle Palmer, B. Penninx, C. Power, M.A. Province, B.M. Psaty, L. Qi, R. Rauramaa, P.M. Ridker, S. Ripatti, V. Salomaa, N.J. Samani, H. Snieder, T.I.A. Sorensen, T.D. Spector, K. Stefansson, A. Tonjes, J. Tuomilehto, A.G. Uitterlinden, M. Uusitupa, P. Van Der Harst, P. Vollenweider, H. Wallaschofski, N.J. Wareham, H. Watkins, H. Erichwichmann, J.H. Wilson, G.R. Abecasis, T.L. Assimes, I. Barroso, M. Boehnke, I.B. Borecki, P. Deloukas, C.S. Fox, T. Frayling, L.C. Groop, T. Haritunian, I.M. Heid, D. Hunter, R.C. Kaplan, F. Karpe, M. Moffatt, K.L. Mohlke, J.R. O'Connell, Y. Pawitan, E.E. Schadt, D. Schlessinger, V. Steinthorsdottir, D.P. Strachan, U. Thorsteindottir, C.M. Van Duijn, P.M. Visscher, A.M. Di Blasio, J.N. Hirschhorn, C.M. Lindgren, A.P. Morris, D. Meyre, A. Scherag, M.I. Mccarthy, E.K. Speliotes, J. Hirschhorn, K.E. North, R.J.F. Loos, E. Ingelsson

Research output: Contribution to journalArticle

37 Citations (Scopus)
Original languageEnglish
Pages (from-to)236-248
JournalAmerican Journal of Human Genetics
Volume93
DOIs
Publication statusPublished - 2013

Cite this

Hu, Y-J., Berndt, S. I., Gustafsson, S., Ganna, A., Magi, R., Wheeler, E., ... Ingelsson, E. (2013). Meta-analysis of gene-level associations for rare variants based on single-variant statistics. American Journal of Human Genetics, 93, 236-248. https://doi.org/10.1016/j.ajhg.2013.06.011