TY - JOUR
T1 - Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China
AU - Wang, Yuan-Yuan
AU - Jin, Yu
AU - Chen, Chang
AU - Zheng, Wei
AU - Wang, Shi-Bin
AU - Ungvari, Gabor S.
AU - Ng, Chee H.
AU - Zhang, Xiaohua Douglas
AU - Wang, Gang
AU - Xiang, Yu-Tao
PY - 2019/8/3
Y1 - 2019/8/3
N2 - With the widespread implementation of antiretroviral therapy in many countries, the HIV/AIDS epidemic has declined. However, little is known about the prevalence of adherence rate to Highly Active Antiretroviral Therapy (HAART) in patients with HIV infection in China. This is the first meta-analysis of cross-sectional studies of treatment adherence ( 95%) to HAART in Chinese patients. Both English (PubMed, PsycINFO, EMBASE, and Web of Science) and Chinese (WanFang, CNKI, and SinoMed) databases were systematically and independently searched by three investigators. Studies with adherence rate estimates of HAART were included. Adherence rate estimates of each eligible study were extracted and pooled using the random-effects model. A total of 40 studies conducted in China were eligible and analyzed. The mean rate of95% adherence to HAART was 81.1% (95%CI: 75.1%-88.0%, I-2=97.3%) at one week, 80.9% (95%CI: 74.7%-85.9%, I-2=96.6%) at one month, and 68.3% (95%CI: 46.1%-84.4%, I-2=97.1%) at 3 months or longer. Subgroup analyses revealed that samples with no gender predominance, low education level, middle economic region, rural area, older age (42.3 years), and recent publication (2013 or later) were correlated to higher HAART adherence. The average rate of HAART adherence was relatively high in China, which indicates effective HIV/AIDS policy, prevention and control measures. However, the HAART adherence rate decreased over the study time period.
AB - With the widespread implementation of antiretroviral therapy in many countries, the HIV/AIDS epidemic has declined. However, little is known about the prevalence of adherence rate to Highly Active Antiretroviral Therapy (HAART) in patients with HIV infection in China. This is the first meta-analysis of cross-sectional studies of treatment adherence ( 95%) to HAART in Chinese patients. Both English (PubMed, PsycINFO, EMBASE, and Web of Science) and Chinese (WanFang, CNKI, and SinoMed) databases were systematically and independently searched by three investigators. Studies with adherence rate estimates of HAART were included. Adherence rate estimates of each eligible study were extracted and pooled using the random-effects model. A total of 40 studies conducted in China were eligible and analyzed. The mean rate of95% adherence to HAART was 81.1% (95%CI: 75.1%-88.0%, I-2=97.3%) at one week, 80.9% (95%CI: 74.7%-85.9%, I-2=96.6%) at one month, and 68.3% (95%CI: 46.1%-84.4%, I-2=97.1%) at 3 months or longer. Subgroup analyses revealed that samples with no gender predominance, low education level, middle economic region, rural area, older age (42.3 years), and recent publication (2013 or later) were correlated to higher HAART adherence. The average rate of HAART adherence was relatively high in China, which indicates effective HIV/AIDS policy, prevention and control measures. However, the HAART adherence rate decreased over the study time period.
KW - HIV
KW - highly active antiretroviral therapy
KW - China
KW - meta-analysis
KW - cross-sectional studies
KW - HIV/AIDS PATIENTS
KW - DRUG-RESISTANCE
KW - SCHIZOPHRENIA
KW - MEDICATION
KW - MORTALITY
KW - AIDS
U2 - 10.1080/09540121.2018.1554238
DO - 10.1080/09540121.2018.1554238
M3 - Article
C2 - 30554523
SN - 0954-0121
VL - 31
SP - 913
EP - 922
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
IS - 8
ER -