Mesoporous silica nanorods toward efficient loading and intracellular delivery of siRNA

Lijue Chen, Xiaodong She, Tao Wang, Sarah Shigdar, Wei Duan, Lingxue Kong

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The technology of RNA interference (RNAi) that uses small interfering RNA (siRNA) to silence the gene expression with complementary messenger RNA (mRNA) sequence has great potential for the treatment of cancer in which certain genes were usually found overexpressed. However, the carry and delivery of siRNA to the target site in the human body can be challenging for this technology to be used clinically to silence the cancer-related gene expression. In this work, rod shaped mesoporous silica nanoparticles (MSNs) were developed as siRNA delivery system for specific intracellular delivery. The rod MSNs with an aspect ratio of 1.5 had a high surface area of 934.28 m2/g and achieved a siRNA loading of more than 80 mg/g. With the epidermal growth factor (EGF) grafted on the surface of the MSNs, siRNA can be delivered to the epidermal growth factor receptor (EGFR) overexpressed colorectal cancer cells with high intracellular concentration compared to MSNs without EGF and lead to survivin gene knocking down to less than 30%.
Original languageEnglish
Article number37
JournalJournal of Nanoparticle Research
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

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