Mesenchymal stem cells as vectors for lung cancer therapy

K.K. Kolluri; Geoff Laurent; S.M. Janes

doi:10.1159/000351284

Mesenchymal stem cells as vectors for lung cancer therapy

K.K. Kolluri, Geoff Laurent, S.M. Janes

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies. Mesenchymal stem cells (MSCs) possess the ability to specifically home into tumours and their metastases. This property of MSCs could be exploited for the delivery of various anti-tumour agents directly into tumours. However, MSCs are not simple delivery vehicles but cells with active physiological process. This review outlines various agents which can be delivered by MSCs with substantial emphasis on TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). Copyright © 2013 S. Karger AG, Basel.

Original language	English
Pages (from-to)	443-451
Journal	Respiration
Volume	85
Issue number	6
DOIs	https://doi.org/10.1159/000351284
Publication status	Published - 2013

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AB - Despite recent advances in treatment, lung cancer accounts for one third of all cancer-related deaths, underlining the need of development of new therapies. Mesenchymal stem cells (MSCs) possess the ability to specifically home into tumours and their metastases. This property of MSCs could be exploited for the delivery of various anti-tumour agents directly into tumours. However, MSCs are not simple delivery vehicles but cells with active physiological process. This review outlines various agents which can be delivered by MSCs with substantial emphasis on TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). Copyright © 2013 S. Karger AG, Basel.

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Mesenchymal stem cells as vectors for lung cancer therapy

Abstract

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