Meroterpenoid and diphenyl ether derivatives from penicillium sp. MA-37, a fungus isolated from marine mangrove rhizospheric soil

Yi Zhang, Xiao Ming Li, Zhuo Shang, Chun Shun Li, Nai Yun Ji, Bin Gui Wang

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Penicillium sp. MA-37, which was obtained from the rhizospheric soil of the mangrove plant Bruguiera gymnorrhiza, exhibited different chemical profiles in static and shaken fermentation modes. Three new meroterpenoid derivatives, 4,25-dehydrominiolutelide B (1), 4,25-dehydro-22-deoxyminiolutelide B (2), and isominiolutelide A (3), together with three known ones were characterized from its static fermentation, while three new diphenyl ether derivatives, namely, Δ1′,3′-1′- dehydroxypenicillide (4), 7-O-acetylsecopenicillide C (5), and hydroxytenellic acid B (6), along with five related metabolites were isolated from the shaken culture. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and the structure of compound 2 was confirmed by X-ray crystallographic analysis. The absolute configurations of 1-3 and 6 were determined by ECD and modified Moshers method, respectively. All isolated compounds were evaluated for brine shrimp lethality and antibacterial activity.

Original languageEnglish
Pages (from-to)1888-1895
Number of pages8
JournalJournal of Natural Products
Volume75
Issue number11
DOIs
Publication statusPublished - 2012
Externally publishedYes

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