Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory

Peter Richmond, E. Miller, S. Clark, F. Sadler, N. Begg, R. Morris, K. Cartwright, R. Borrow, A. Fox

    Research output: Contribution to journalArticle

    205 Citations (Scopus)

    Abstract

    The safety, immunogenicity, and immunologic priming of 2 dosages (2 mu g or 10 mu g) of a meningococcal C oligosaccharide-CRM197 conjugate vaccine was evaluated in 114 infants vaccinated at ages 2, 3, and 4 months. Antibody persistence and response to boosting with 10 ag Of meningococcal C polysaccharide were assessed. The meningococcal conjugate vaccine produced fewer local reactions than concurrent routine immunizations. Total serogroup C-specific immunoglobulin geometric mean concentration (GMC) increased from 0.3 mu g/mL before vaccination to 13.1 mu g/mL at age 5 months. Serum bactericidal antibody (SBA) geometric mean titers (GMTs) rose from
    Original languageEnglish
    Pages (from-to)1569-1572
    JournalJournal of Infectious Diseases
    Volume179
    Issue number6
    DOIs
    Publication statusPublished - 1999

    Fingerprint

    Dive into the research topics of 'Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory'. Together they form a unique fingerprint.

    Cite this