Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory

Peter Richmond; E. Miller; S. Clark; F. Sadler; N. Begg; R. Morris; K. Cartwright; R. Borrow; A. Fox

doi:10.1086/314753

Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory

Peter Richmond, E. Miller, S. Clark, F. Sadler, N. Begg, R. Morris, K. Cartwright, R. Borrow, A. Fox

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Abstract

The safety, immunogenicity, and immunologic priming of 2 dosages (2 mu g or 10 mu g) of a meningococcal C oligosaccharide-CRM197 conjugate vaccine was evaluated in 114 infants vaccinated at ages 2, 3, and 4 months. Antibody persistence and response to boosting with 10 ag Of meningococcal C polysaccharide were assessed. The meningococcal conjugate vaccine produced fewer local reactions than concurrent routine immunizations. Total serogroup C-specific immunoglobulin geometric mean concentration (GMC) increased from 0.3 mu g/mL before vaccination to 13.1 mu g/mL at age 5 months. Serum bactericidal antibody (SBA) geometric mean titers (GMTs) rose from

Original language	English
Pages (from-to)	1569-1572
Journal	Journal of Infectious Diseases
Volume	179
Issue number	6
DOIs	https://doi.org/10.1086/314753
Publication status	Published - 1999

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10.1086/314753

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title = "Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory",

abstract = "The safety, immunogenicity, and immunologic priming of 2 dosages (2 mu g or 10 mu g) of a meningococcal C oligosaccharide-CRM197 conjugate vaccine was evaluated in 114 infants vaccinated at ages 2, 3, and 4 months. Antibody persistence and response to boosting with 10 ag Of meningococcal C polysaccharide were assessed. The meningococcal conjugate vaccine produced fewer local reactions than concurrent routine immunizations. Total serogroup C-specific immunoglobulin geometric mean concentration (GMC) increased from 0.3 mu g/mL before vaccination to 13.1 mu g/mL at age 5 months. Serum bactericidal antibody (SBA) geometric mean titers (GMTs) rose from",

author = "Peter Richmond and E. Miller and S. Clark and F. Sadler and N. Begg and R. Morris and K. Cartwright and R. Borrow and A. Fox",

year = "1999",

doi = "10.1086/314753",

language = "English",

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T1 - Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory

AU - Richmond, Peter

AU - Miller, E.

AU - Clark, S.

AU - Sadler, F.

AU - Begg, N.

AU - Morris, R.

AU - Cartwright, K.

AU - Borrow, R.

AU - Fox, A.

PY - 1999

Y1 - 1999

N2 - The safety, immunogenicity, and immunologic priming of 2 dosages (2 mu g or 10 mu g) of a meningococcal C oligosaccharide-CRM197 conjugate vaccine was evaluated in 114 infants vaccinated at ages 2, 3, and 4 months. Antibody persistence and response to boosting with 10 ag Of meningococcal C polysaccharide were assessed. The meningococcal conjugate vaccine produced fewer local reactions than concurrent routine immunizations. Total serogroup C-specific immunoglobulin geometric mean concentration (GMC) increased from 0.3 mu g/mL before vaccination to 13.1 mu g/mL at age 5 months. Serum bactericidal antibody (SBA) geometric mean titers (GMTs) rose from

AB - The safety, immunogenicity, and immunologic priming of 2 dosages (2 mu g or 10 mu g) of a meningococcal C oligosaccharide-CRM197 conjugate vaccine was evaluated in 114 infants vaccinated at ages 2, 3, and 4 months. Antibody persistence and response to boosting with 10 ag Of meningococcal C polysaccharide were assessed. The meningococcal conjugate vaccine produced fewer local reactions than concurrent routine immunizations. Total serogroup C-specific immunoglobulin geometric mean concentration (GMC) increased from 0.3 mu g/mL before vaccination to 13.1 mu g/mL at age 5 months. Serum bactericidal antibody (SBA) geometric mean titers (GMTs) rose from

U2 - 10.1086/314753

DO - 10.1086/314753

M3 - Article

SN - 0022-1899

VL - 179

SP - 1569

EP - 1572

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 6

ER -

Meningococcal serogroup C conjugate vaccine is immunogenic in infancy and primes for memory

Abstract

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