Memory networks in tinnitus: A functional brain image study

M.R. Laureano, E. Onishi, R.A. Bressan, M.L.V. Castiglioni, I.R. Batista, M.A.D. Reis, M.V. Garcia, A.N. De Andrade, R.R. De Almeida, Griselda Garrido, A.P. Jackowski

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)


    Tinnitus is characterized by the perception of sound in the absence of an external auditory stimulus. The network connectivity of auditory and non-auditory brain structures associated with emotion, memory and attention are functionally altered in debilitating tinnitus. Current studies suggest that tinnitus results from neuroplastic changes in the frontal and limbic temporal regions. The objective of this study was to use Single-Photon Emission Computed Tomography (SPECT) to evaluate changes in the cerebral blood flow in tinnitus patients with normal hearing compared with healthy controls. Methods: Twenty tinnitus patients with normal hearing and 17 healthy controls, matched for sex, age and years of education, were subjected to Single Photon Emission Computed Tomography using the radiotracer ethylenedicysteine diethyl ester, labeled with Technetium 99 m (99 mTc-ECD SPECT). The severity of tinnitus was assessed using the "Tinnitus Handicap Inventory" (THI). The images were processed and analyzed using "Statistical Parametric Mapping" (SPM8). Results: A significant increase in cerebral perfusion in the left parahippocampal gyrus (pFWE
    Original languageEnglish
    Pages (from-to)5pp
    JournalPLoS One
    Issue number2
    Publication statusPublished - 2014


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