Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

C.M. Snyder, K.S. Cho, E.L. Bonnett, S. Van Dommelen, Geoffrey Shellam, A.B. Hill

    Research output: Contribution to journalArticle

    208 Citations (Scopus)

    Abstract

    During persistent murine cytomegalovirus (MCMV) infection, the T cell response is maintained at extremely high intensity for the life of the host. These cells closely resemble human CMV-specific cells, which compose a major component of the peripheral T cell compartment in most people. Despite a phenotype that suggests extensive antigen-driven differentiation, MCMV-specific T cells remain functional and respond vigorously to viral challenge. We hypothesized that a low rate of antigen-driven proliferation would account for the maintenance of this population. Instead, we found that most of these cells divided only sporadically in chronically infected hosts and had a short half-life in circulation. The overall population was supported, at least in part, by memory T cells primed early in infection, as well as by recruitment of naive T cells at late times. Thus, these data show that memory inflation is maintained by a continuous replacement of short-lived, functional cells during chronic MCMV infection.
    Original languageEnglish
    Pages (from-to)650-659
    JournalImmunity
    Volume29
    Issue number4
    DOIs
    Publication statusPublished - 2008

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