Medication adherence during adjunct therapy with statins and ACE inhibitors in adolescents with type 1 diabetes

on behalf of the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group*

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim was to assess adherence to ACE inhibitors and statins and explore potential determinants in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS There were 443 adolescents with type 1 diabetes recruited into the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) and exposed to treatment with two oral drugsdan ACE inhibitor and a statindas well as combinations of both or placebo for 2–4 years. Adherence was assessed every 3 months with the Medication Event Monitoring System (MEMS) and pill count. RESULTS Median adherence during the trial was 80.2% (interquartile range 63.6–91.8) based on MEMS and 85.7% (72.4–92.9) for pill count. Adherence based on MEMS and pill count dropped from 92.9% and 96.3%, respectively, at the first visit to 76.3% and 79.0% at the end of the trial. The percentage of study participants with adherence ≥75% declined from 84% to 53%. A good correlation was found between adherence based on MEMS and pill count (r 5 0.82, P < 0.001). Factors associated with adherence were age, glycemic control, and country. CONCLUSIONS We report an overall good adherence to ACE inhibitors and statins during a clinical trial, although there was a clear decline in adherence over time. Older age and suboptimal glycemic control at baseline predicted lower adherence during the trial, and, predictably, reduced adherence was more prevalent in subjects who subsequently dropped out.

Original languageEnglish
Pages (from-to)1070-1076
Number of pages7
JournalDiabetes Care
Volume43
Issue number5
DOIs
Publication statusPublished - 1 May 2020

Fingerprint Dive into the research topics of 'Medication adherence during adjunct therapy with statins and ACE inhibitors in adolescents with type 1 diabetes'. Together they form a unique fingerprint.

  • Cite this

    on behalf of the Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group* (2020). Medication adherence during adjunct therapy with statins and ACE inhibitors in adolescents with type 1 diabetes. Diabetes Care, 43(5), 1070-1076. https://doi.org/10.2337/dc19-0884