Mechanotransduction plays an essential role in maintaining tendon homeostasis

Ziming Chen

doi:10.26182/cpgb-w145

Mechanotransduction plays an essential role in maintaining tendon homeostasis

Ziming Chen

Research output: Thesis › Doctoral Thesis

13 Downloads (Pure)

Abstract

Mechanobiology is a discipline investigating the influence of mechanical stress in life science. Tendon connects muscle at the myotendinous junction to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Daily repetitive stretching on tendon makes tendon an ideal model for mechanobiology study. This thesis summarizes and explores the role of mechanical force in tendon homeostasis. We provide novel insights into the regulation of cell metabolism during physiological and pathological mechanical environments that have implications for our understanding of tendon disease and other mechanotransduction related diseases.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Zheng, Minghao, Supervisor Wood, David, Supervisor Tai, Andrew, Supervisor
Award date	22 May 2024
DOIs	https://doi.org/10.26182/cpgb-w145
Publication status	Unpublished - 2023

Embargo information

Embargoed from 20/05/2024 to 26/04/2026. Made publicly available on 26/04/2026.

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10.26182/cpgb-w145

THESIS - DOCTOR OF PHILOSOPHY - CHEN Ziming - 2023

1 Chapter
1 Review article

Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside
Chen, Z., Chen, P., Zheng, M., Gao, J., Liu, D., Wang, A., Zheng, Q., Leys, T., Tai, A. & Zheng, M., Dec 2022, In: Stem Cell Research & Therapy. 13, 1, 21 p., 444.
Research output: Contribution to journal › Review article › peer-review

Open Access
30 Link opens in a new tab Citations (Scopus)
In Vitro 3D Mechanical Stimulation to Tendon-Derived Stem Cells by Bioreactor
Chen, Z., Chen, P., Ruan, R. & Zheng, M., 2022, Bioreactors in Stem Cell Biology: Methods and Protocols. Turksen, K. (ed.). 2nd ed. USA: Humana Press Inc., p. 135-144 10 p. (Methods in Molecular Biology; vol. 2436).
Research output: Chapter in Book/Conference paper › Chapter › peer-review
7 Link opens in a new tab Citations (Scopus)

Cite this

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abstract = "Mechanobiology is a discipline investigating the influence of mechanical stress in life science. Tendon connects muscle at the myotendinous junction to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Daily repetitive stretching on tendon makes tendon an ideal model for mechanobiology study. This thesis summarizes and explores the role of mechanical force in tendon homeostasis. We provide novel insights into the regulation of cell metabolism during physiological and pathological mechanical environments that have implications for our understanding of tendon disease and other mechanotransduction related diseases.",

keywords = "Mechanobiology, Tendon, Tendinopathy, Mitochondrion, Endoplasmic reticulum",

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AB - Mechanobiology is a discipline investigating the influence of mechanical stress in life science. Tendon connects muscle at the myotendinous junction to bone at the enthesis and allowing mechanical force to transmit from muscle to bone. Daily repetitive stretching on tendon makes tendon an ideal model for mechanobiology study. This thesis summarizes and explores the role of mechanical force in tendon homeostasis. We provide novel insights into the regulation of cell metabolism during physiological and pathological mechanical environments that have implications for our understanding of tendon disease and other mechanotransduction related diseases.

KW - Mechanobiology

KW - Tendon

KW - Tendinopathy

KW - Mitochondrion

KW - Endoplasmic reticulum

U2 - 10.26182/cpgb-w145

DO - 10.26182/cpgb-w145

M3 - Doctoral Thesis

ER -

Mechanotransduction plays an essential role in maintaining tendon homeostasis

Abstract

Embargo information

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Research output

Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside

In Vitro 3D Mechanical Stimulation to Tendon-Derived Stem Cells by Bioreactor

Cite this