Mechanosensitive channel of large conductance

A. Kloda, E. Petrov, G.R. Meyer, T.N. Nguyen, A.C. Hurst, Livia Hool, B. Martinac

Research output: Contribution to journalReview article

29 Citations (Scopus)
284 Downloads (Pure)

Abstract

Microbial cells constitutively express the Large Conductance Mechanosensitive Channel which opens in response to stretch forces in the lipid bilayer. The channel protein forms a homopentamer with each subunit containing two transmembrane regions and gates via the bilayer mechanism evoked by hydrophobic mismatch and changes in the membrane curvature and/or transbilayer pressure profile. During the stationary phase and during osmotic shock the channel protein is up-regulated to prevent cell lysis. Pharmacological potential of MscL may involve discovery of new age antibiotics to combat multiple drug-resistant bacterial strains.
Original languageEnglish
Pages (from-to)164-169
JournalThe International Journal of Biochemistry & Cell Biology
Volume40
Issue number2
DOIs
Publication statusPublished - 2008

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