Mechanosensitive channel of large conductance

A. Kloda; E. Petrov; G.R. Meyer; T.N. Nguyen; A.C. Hurst; Livia Hool; B. Martinac

doi:10.1016/j.biocel.2007.02.003

Mechanosensitive channel of large conductance

A. Kloda, E. Petrov, G.R. Meyer, T.N. Nguyen, A.C. Hurst, Livia Hool, B. Martinac

School of Molecular Sciences

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Abstract

Microbial cells constitutively express the Large Conductance Mechanosensitive Channel which opens in response to stretch forces in the lipid bilayer. The channel protein forms a homopentamer with each subunit containing two transmembrane regions and gates via the bilayer mechanism evoked by hydrophobic mismatch and changes in the membrane curvature and/or transbilayer pressure profile. During the stationary phase and during osmotic shock the channel protein is up-regulated to prevent cell lysis. Pharmacological potential of MscL may involve discovery of new age antibiotics to combat multiple drug-resistant bacterial strains.

Original language	English
Pages (from-to)	164-169
Journal	The International Journal of Biochemistry & Cell Biology
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.biocel.2007.02.003
Publication status	Published - 2008

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title = "Mechanosensitive channel of large conductance",

abstract = "Microbial cells constitutively express the Large Conductance Mechanosensitive Channel which opens in response to stretch forces in the lipid bilayer. The channel protein forms a homopentamer with each subunit containing two transmembrane regions and gates via the bilayer mechanism evoked by hydrophobic mismatch and changes in the membrane curvature and/or transbilayer pressure profile. During the stationary phase and during osmotic shock the channel protein is up-regulated to prevent cell lysis. Pharmacological potential of MscL may involve discovery of new age antibiotics to combat multiple drug-resistant bacterial strains.",

author = "A. Kloda and E. Petrov and G.R. Meyer and T.N. Nguyen and A.C. Hurst and Livia Hool and B. Martinac",

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journal = "The International Journal of Biochemistry & Cell Biology",

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T1 - Mechanosensitive channel of large conductance

AU - Kloda, A.

AU - Petrov, E.

AU - Meyer, G.R.

AU - Nguyen, T.N.

AU - Hurst, A.C.

AU - Hool, Livia

AU - Martinac, B.

PY - 2008

Y1 - 2008

N2 - Microbial cells constitutively express the Large Conductance Mechanosensitive Channel which opens in response to stretch forces in the lipid bilayer. The channel protein forms a homopentamer with each subunit containing two transmembrane regions and gates via the bilayer mechanism evoked by hydrophobic mismatch and changes in the membrane curvature and/or transbilayer pressure profile. During the stationary phase and during osmotic shock the channel protein is up-regulated to prevent cell lysis. Pharmacological potential of MscL may involve discovery of new age antibiotics to combat multiple drug-resistant bacterial strains.

AB - Microbial cells constitutively express the Large Conductance Mechanosensitive Channel which opens in response to stretch forces in the lipid bilayer. The channel protein forms a homopentamer with each subunit containing two transmembrane regions and gates via the bilayer mechanism evoked by hydrophobic mismatch and changes in the membrane curvature and/or transbilayer pressure profile. During the stationary phase and during osmotic shock the channel protein is up-regulated to prevent cell lysis. Pharmacological potential of MscL may involve discovery of new age antibiotics to combat multiple drug-resistant bacterial strains.

U2 - 10.1016/j.biocel.2007.02.003

DO - 10.1016/j.biocel.2007.02.003

M3 - Review article

SN - 1357-2725

VL - 40

SP - 164

EP - 169

JO - The International Journal of Biochemistry & Cell Biology

JF - The International Journal of Biochemistry & Cell Biology

IS - 2

ER -

Mechanosensitive channel of large conductance

Abstract

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