The mechanism of the positive cardioactive effects induced by verbascoside in the Lagendorff rat heart has been investigated. Isolated rat hearts treated with alpha- or beta-adrenergic agents did not show significant reduction of the positive chronotropism, inotropism and increased coronary perfusion rate mediated by verbascoside. A significant increase in prostacyclin levels (142%) observed following the administration of verbascoside suggests that prostacyclin stimulates formation of cAMP which induces the cardioactivity associated with verbascoside. Copyright (C) 1999 John Wiley & Sons, Ltd.
|Publication status||Published - 1999|
Pennacchio, M., Syah, Y. M., Alexander, E., & Ghisalberti, E. (1999). Mechanism of action of verbascoside on the isolated rat heart: increases in level of prostacyclin. Phytotherapy Research, 13(N/A), 254-255. https://doi.org/10.1002/(SICI)1099-1573(199905)13:3<254::AID-PTR430>3.0.CO;2-1