Mechanics and biology at the interface of life: Growing our understanding of the placenta

Nikhilesh Bappoo

Research output: ThesisDoctoral Thesis

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Abstract

Placental vasculature and blood flow are important determinants of fetal growth, thus unsurprisingly, impairments often underly the pathophysiology of small for gestational age fetuses which have worse health outcomes at birth and later in adulthood. Currently, the capacity to ethically research and accurately detect placental insufficiency in utero is limited. This thesis is positioned at the intersection of biomedical engineering and developmental biology and leverages 3D imaging and computational fluid dynamics simulations of blood flow in the placenta to provide novel and translatable insights into feto-placental biomechanics, in both healthy and growth restricted fetuses
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Doyle, Barry, Supervisor
  • Wyrwoll, Caitlin, Supervisor
  • Kelsey, Lachlan, Supervisor
Thesis sponsors
Award date20 Nov 2023
DOIs
Publication statusUnpublished - 2023

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