Projects per year
Abstract
Alleviating bone loss is an essential way to prevent osteoporotic fractures. Proper exercise improves bone density without the side effects of long-term medications, but the mechanism is unclear. Our study explored the role of Antxr1/LncRNA H19/Wnt/β-catenin axis in the process of exercise-mediated alleviation of bone loss. Here we discovered that moderate-intensity treadmill exercise alleviates bone loss caused by ovariectomy and ameliorates bone strength accompanied by an increased lncRNA H19 expression. Concomitantly, Antxr1, a mechanosensitive protein was found downregulated by exercise but upregulated by ovariectomy. Interestingly, knockdown expression of Antxr1 increased lncRNA H19 expression and Wnt/β-catenin signaling pathway in bone marrow mesenchymal stem cells, whereas overexpression of Antxr1 decreased lncRNA H19 expression and Wnt/β-catenin signaling pathway. Hence, our study demonstrates the regulation of Antxr1/LncRNA H19/Wnt/β-catenin axis in the process of mechanical strain-induced osteogenic differentiation, which provides further mechanistic insight into the role of mechanical regulation in bone metabolism.
Original language | English |
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Article number | e31214 |
Number of pages | 11 |
Journal | Journal of Cellular Physiology |
Volume | 239 |
Issue number | 5 |
Early online date | 15 Feb 2024 |
DOIs | |
Publication status | Published - May 2024 |
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‘Sorting-Out’ the molecular link between SNX10 and Autophagy in Osteoclasts
Xu, J. (Investigator 01), Pavlos, N. (Investigator 02) & Tickner, J. (Investigator 03)
NHMRC National Health and Medical Research Council
1/01/19 → 31/12/22
Project: Research