Measuring protein concentration with entangled photons

Andrea Crespi; Mirko Lobino; Jonathan C.F. Matthews; Alberto Politi; Chris R. Neal; Roberta Ramponi; Roberto Osellame; Jeremy L. O'Brien

doi:10.1063/1.4724105

Measuring protein concentration with entangled photons

Andrea Crespi, Mirko Lobino, Jonathan C.F. Matthews, Alberto Politi, Chris R. Neal, Roberta Ramponi, Roberto Osellame, Jeremy L. O'Brien

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Abstract

Optical interferometry is amongst the most sensitive techniques for precision measurement. By increasing the light intensity, a more precise measurement can usually be made. However, if the sample is light sensitive entangled states can achieve the same precision with less exposure. This concept has been demonstrated in measurements of known optical components. Here, we use two-photon entangled states to measure the concentration of a blood protein in an aqueous buffer solution. We use an opto-fluidic device that couples a waveguide interferometer with a microfluidic channel. These results point the way to practical applications of quantum metrology to light-sensitive samples.

Original language	English
Article number	233704
Journal	Applied Physics Letters
Volume	100
Issue number	23
DOIs	https://doi.org/10.1063/1.4724105
Publication status	Published - 4 Jun 2012
Externally published	Yes

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AU - Lobino, Mirko

AU - Matthews, Jonathan C.F.

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AU - Neal, Chris R.

AU - Ramponi, Roberta

AU - Osellame, Roberto

AU - O'Brien, Jeremy L.

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AB - Optical interferometry is amongst the most sensitive techniques for precision measurement. By increasing the light intensity, a more precise measurement can usually be made. However, if the sample is light sensitive entangled states can achieve the same precision with less exposure. This concept has been demonstrated in measurements of known optical components. Here, we use two-photon entangled states to measure the concentration of a blood protein in an aqueous buffer solution. We use an opto-fluidic device that couples a waveguide interferometer with a microfluidic channel. These results point the way to practical applications of quantum metrology to light-sensitive samples.

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Measuring protein concentration with entangled photons

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