Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography

Barry Cense, Donald T Miller, Brett J King, Thomas Theelen, Ann E Elsner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However, earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (54 years) subjects. All young subjects and 5 of the older subjects had retardance values induced by the retinal pigment epithelium and Bruch's membrane (RPE-BM) complex that were just above the noise floor measurement (5°-13° at 840 nm). In contrast, elevated retardance, up to 180°, was observed in the other 5 older subjects. Analysis of the degree of polarization uniformity (DOPU) demonstrates that reduced DOPU (

Original languageEnglish
Article numbere201700134
JournalJournal of Biophotonics
Volume11
Issue number5
DOIs
Publication statusPublished - May 2018
Externally publishedYes

Fingerprint

Bruch Membrane
Retinal Pigment Epithelium
retina
Optical tomography
Optical Coherence Tomography
Macular Degeneration
Retina
Early Diagnosis
tomography
Biomarkers
Polarization
polarization
Retinal Pigments
degeneration
epithelium
biomarkers
pigments
bears
Pigments
Tissue

Cite this

Cense, Barry ; Miller, Donald T ; King, Brett J ; Theelen, Thomas ; Elsner, Ann E. / Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography. In: Journal of Biophotonics. 2018 ; Vol. 11, No. 5.
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Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography. / Cense, Barry; Miller, Donald T; King, Brett J; Theelen, Thomas; Elsner, Ann E.

In: Journal of Biophotonics, Vol. 11, No. 5, e201700134, 05.2018.

Research output: Contribution to journalArticle

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AU - Cense, Barry

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