Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography

Barry Cense, Donald T Miller, Brett J King, Thomas Theelen, Ann E Elsner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However, earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (54 years) subjects. All young subjects and 5 of the older subjects had retardance values induced by the retinal pigment epithelium and Bruch's membrane (RPE-BM) complex that were just above the noise floor measurement (5°-13° at 840 nm). In contrast, elevated retardance, up to 180°, was observed in the other 5 older subjects. Analysis of the degree of polarization uniformity (DOPU) demonstrates that reduced DOPU (

Original languageEnglish
Article numbere201700134
JournalJournal of Biophotonics
Volume11
Issue number5
DOIs
Publication statusPublished - May 2018
Externally publishedYes

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