Abstract
ObjectiveTo assess the effect of topical betahistine on Eustachian tube function in subjectively abnormal subjects in a hyperbaric chamber.MethodActive and passive Eustachian tube function was examined using tympanometry in a pressure chamber.ResultsActive Eustachian tube function was tested against the negative middle ear pressure induced by increasing the chamber pressure to +3 kPa. One voluntary swallow decreased middle-ear pressure by a mean of 1.36 kPa. Passive Eustachian tube function was tested by measuring spontaneous Eustachian tube openings as the chamber pressure dropped from +10 kPa to ambient. Four distinct patterns of Eustachian tube behaviour were seen, three of which indicated Eustachian tube dysfunction. Betahistine had no positive effect on Eustachian tube opening, although previous animal studies had suggested a beneficial effect.ConclusionTopical betahistine had no effect on Eustachian tube function. Combining a hyperbaric chamber with tympanometry proved ideal for evaluating Eustachian tube function.
| Original language | English |
|---|---|
| Journal | Journal of Laryngology and Otology |
| DOIs | |
| Publication status | E-pub ahead of print - 24 Jun 2019 |
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Measuring dynamic Eustachian tube function using tympanometry in a pressure chamber : The effect of nasal betahistine application. / Franz, B. K.H.G.; Patuzzi, R.; Wraight, C. J.; Kay, G.; Ng, A.; Anderson, Colin R.
In: Journal of Laryngology and Otology, 24.06.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Measuring dynamic Eustachian tube function using tympanometry in a pressure chamber
T2 - The effect of nasal betahistine application
AU - Franz, B. K.H.G.
AU - Patuzzi, R.
AU - Wraight, C. J.
AU - Kay, G.
AU - Ng, A.
AU - Anderson, Colin R.
PY - 2019/6/24
Y1 - 2019/6/24
N2 - ObjectiveTo assess the effect of topical betahistine on Eustachian tube function in subjectively abnormal subjects in a hyperbaric chamber.MethodActive and passive Eustachian tube function was examined using tympanometry in a pressure chamber.ResultsActive Eustachian tube function was tested against the negative middle ear pressure induced by increasing the chamber pressure to +3 kPa. One voluntary swallow decreased middle-ear pressure by a mean of 1.36 kPa. Passive Eustachian tube function was tested by measuring spontaneous Eustachian tube openings as the chamber pressure dropped from +10 kPa to ambient. Four distinct patterns of Eustachian tube behaviour were seen, three of which indicated Eustachian tube dysfunction. Betahistine had no positive effect on Eustachian tube opening, although previous animal studies had suggested a beneficial effect.ConclusionTopical betahistine had no effect on Eustachian tube function. Combining a hyperbaric chamber with tympanometry proved ideal for evaluating Eustachian tube function.
AB - ObjectiveTo assess the effect of topical betahistine on Eustachian tube function in subjectively abnormal subjects in a hyperbaric chamber.MethodActive and passive Eustachian tube function was examined using tympanometry in a pressure chamber.ResultsActive Eustachian tube function was tested against the negative middle ear pressure induced by increasing the chamber pressure to +3 kPa. One voluntary swallow decreased middle-ear pressure by a mean of 1.36 kPa. Passive Eustachian tube function was tested by measuring spontaneous Eustachian tube openings as the chamber pressure dropped from +10 kPa to ambient. Four distinct patterns of Eustachian tube behaviour were seen, three of which indicated Eustachian tube dysfunction. Betahistine had no positive effect on Eustachian tube opening, although previous animal studies had suggested a beneficial effect.ConclusionTopical betahistine had no effect on Eustachian tube function. Combining a hyperbaric chamber with tympanometry proved ideal for evaluating Eustachian tube function.
KW - Acoustic Impedance Tests
KW - Betahistine
KW - Ear, Middle
KW - Eustachian Tube
KW - Pressure
UR - http://www.scopus.com/inward/record.url?scp=85067954773&partnerID=8YFLogxK
U2 - 10.1017/S0022215119001270
DO - 10.1017/S0022215119001270
M3 - Article
JO - The Journal of Laryngology & Otology
JF - The Journal of Laryngology & Otology
SN - 0022-2151
ER -