Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications

Mohit Kumar Jolly, Ryan J. Murphy, Sugandha Bhatia, Holly J. Whitfield, Andrew Redfern, Melissa J. Davis, Erik W. Thompson

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.

Original languageEnglish
Pages (from-to)110-133
Number of pages24
JournalCells Tissues Organs
Volume211
Issue number2
Early online date26 Apr 2021
DOIs
Publication statusPublished - 1 Mar 2022

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