TY - JOUR
T1 - Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection
AU - Hung, T.Y.
AU - Davis, Timothy
AU - Ilett, Kenneth
PY - 2003
Y1 - 2003
N2 - Piperaquine (PQ) is an antimalarial drug enjoying a resurgence of use in combination with an artemisinin derivative because of parasite resistance to standard treatments. Its pharmacokinetic properties have not been characterised. An assay for PQ in plasma was developed using solvent extraction and liquid chromatographic separation on a Waters XTerra™ RP18 column, with a mobile phase of 7% acetonitrile in water (containing 0.025% trifluoroacetic acid, 0.1% NaCl and 0.008% triethylamine) and UV detection at 340 nm. The assay was linear up to 1000 μg/l. Intra- and inter-day relative standard deviations were
AB - Piperaquine (PQ) is an antimalarial drug enjoying a resurgence of use in combination with an artemisinin derivative because of parasite resistance to standard treatments. Its pharmacokinetic properties have not been characterised. An assay for PQ in plasma was developed using solvent extraction and liquid chromatographic separation on a Waters XTerra™ RP18 column, with a mobile phase of 7% acetonitrile in water (containing 0.025% trifluoroacetic acid, 0.1% NaCl and 0.008% triethylamine) and UV detection at 340 nm. The assay was linear up to 1000 μg/l. Intra- and inter-day relative standard deviations were
U2 - 10.1016/S1570-0232(03)00209-5
DO - 10.1016/S1570-0232(03)00209-5
M3 - Article
SN - 1570-0232
VL - 791
SP - 93
EP - 101
JO - Journal of Chromatography B
JF - Journal of Chromatography B
IS - 1/2
ER -