Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Piperaquine (PQ) is an antimalarial drug enjoying a resurgence of use in combination with an artemisinin derivative because of parasite resistance to standard treatments. Its pharmacokinetic properties have not been characterised. An assay for PQ in plasma was developed using solvent extraction and liquid chromatographic separation on a Waters XTerra™ RP18 column, with a mobile phase of 7% acetonitrile in water (containing 0.025% trifluoroacetic acid, 0.1% NaCl and 0.008% triethylamine) and UV detection at 340 nm. The assay was linear up to 1000 μg/l. Intra- and inter-day relative standard deviations were
Original languageEnglish
Pages (from-to)93-101
JournalJournal of Chromatography B
Volume791
Issue number1/2
DOIs
Publication statusPublished - 2003

Fingerprint Dive into the research topics of 'Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection'. Together they form a unique fingerprint.

Cite this