Maximum principal AAA wall stress is proportional to wall thickness

K. Miller, G. R. Joldes, J. Qian, A. P. Patel, M. S. Jung, A. C.R. Tavner, A. Wittek

Research output: Chapter in Book/Conference paperChapter

Abstract

Abdominal aortic aneurysm (AAA) is a permanent and irreversible dilation of the lower region of the aorta. It is an asymptomatic condition which if left untreated can expand to the point of rupture. Rupture of an artery will occur when the local wall stress exceeds the local wall strength. Therefore, estimation of a patient's AAA wall stress non-invasively, quickly, and reliably is desirable. One solution to this problem is to use recently-published methods to compute AAA wall stress, using geometry from CT scans, and median arterial pressure as the load. Our method is embedded in the software platform BioPARR-Biomechanics based Prediction of Aneurysm Rupture Risk, freely available from http://bioparr.mech.uwa.edu.au/. Experience with over 50 patient-specific stress analyses, as well as common sense, suggests that the AAA wall stress is critically dependent on the local AAA wall thickness. This thickness is currently very difficult to measure in the clinical environment. Therefore, we conducted a simulation study to elucidate the relationship between the wall thickness and the maximum principal stress. The results of the analysis of three cases presented here unequivocally demonstrate that this relationship is approximately linear, bringing us closer to being able to compute predictive stress envelopes for every patient.

Original languageEnglish
Title of host publicationComputational Biomechanics for Medicine
Subtitle of host publicationMeasurements, Models, and Predictions
EditorsPoul M.F. Nielsen, Karol Miller, Grand R. Joldes, Adam Wittek, Barry Doyle, Martyn P. Nash
Place of PublicationSwitzerland
PublisherSpringer International Publishing AG
Pages43-53
Number of pages11
ISBN (Electronic)9783319755892
ISBN (Print)9783319755885
DOIs
Publication statusPublished - 14 May 2018

Fingerprint

Abdominal Aortic Aneurysm
Rupture
Asymptomatic Diseases
Biomechanical Phenomena
biodynamics
aorta
Aneurysm
Aorta
Dilatation
Biomechanics
Computerized tomography
Arterial Pressure
Software
Arteries
arteries
envelopes
platforms
computer programs
Geometry
geometry

Cite this

Miller, K., Joldes, G. R., Qian, J., Patel, A. P., Jung, M. S., Tavner, A. C. R., & Wittek, A. (2018). Maximum principal AAA wall stress is proportional to wall thickness. In P. M. F. Nielsen, K. Miller, G. R. Joldes, A. Wittek, B. Doyle, & M. P. Nash (Eds.), Computational Biomechanics for Medicine: Measurements, Models, and Predictions (pp. 43-53). Switzerland: Springer International Publishing AG. https://doi.org/10.1007/978-3-319-75589-2_5
Miller, K. ; Joldes, G. R. ; Qian, J. ; Patel, A. P. ; Jung, M. S. ; Tavner, A. C.R. ; Wittek, A. / Maximum principal AAA wall stress is proportional to wall thickness. Computational Biomechanics for Medicine: Measurements, Models, and Predictions. editor / Poul M.F. Nielsen ; Karol Miller ; Grand R. Joldes ; Adam Wittek ; Barry Doyle ; Martyn P. Nash. Switzerland : Springer International Publishing AG, 2018. pp. 43-53
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Miller, K, Joldes, GR, Qian, J, Patel, AP, Jung, MS, Tavner, ACR & Wittek, A 2018, Maximum principal AAA wall stress is proportional to wall thickness. in PMF Nielsen, K Miller, GR Joldes, A Wittek, B Doyle & MP Nash (eds), Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Springer International Publishing AG, Switzerland, pp. 43-53. https://doi.org/10.1007/978-3-319-75589-2_5

Maximum principal AAA wall stress is proportional to wall thickness. / Miller, K.; Joldes, G. R.; Qian, J.; Patel, A. P.; Jung, M. S.; Tavner, A. C.R.; Wittek, A.

Computational Biomechanics for Medicine: Measurements, Models, and Predictions. ed. / Poul M.F. Nielsen; Karol Miller; Grand R. Joldes; Adam Wittek; Barry Doyle; Martyn P. Nash. Switzerland : Springer International Publishing AG, 2018. p. 43-53.

Research output: Chapter in Book/Conference paperChapter

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AU - Miller, K.

AU - Joldes, G. R.

AU - Qian, J.

AU - Patel, A. P.

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AU - Wittek, A.

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N2 - Abdominal aortic aneurysm (AAA) is a permanent and irreversible dilation of the lower region of the aorta. It is an asymptomatic condition which if left untreated can expand to the point of rupture. Rupture of an artery will occur when the local wall stress exceeds the local wall strength. Therefore, estimation of a patient's AAA wall stress non-invasively, quickly, and reliably is desirable. One solution to this problem is to use recently-published methods to compute AAA wall stress, using geometry from CT scans, and median arterial pressure as the load. Our method is embedded in the software platform BioPARR-Biomechanics based Prediction of Aneurysm Rupture Risk, freely available from http://bioparr.mech.uwa.edu.au/. Experience with over 50 patient-specific stress analyses, as well as common sense, suggests that the AAA wall stress is critically dependent on the local AAA wall thickness. This thickness is currently very difficult to measure in the clinical environment. Therefore, we conducted a simulation study to elucidate the relationship between the wall thickness and the maximum principal stress. The results of the analysis of three cases presented here unequivocally demonstrate that this relationship is approximately linear, bringing us closer to being able to compute predictive stress envelopes for every patient.

AB - Abdominal aortic aneurysm (AAA) is a permanent and irreversible dilation of the lower region of the aorta. It is an asymptomatic condition which if left untreated can expand to the point of rupture. Rupture of an artery will occur when the local wall stress exceeds the local wall strength. Therefore, estimation of a patient's AAA wall stress non-invasively, quickly, and reliably is desirable. One solution to this problem is to use recently-published methods to compute AAA wall stress, using geometry from CT scans, and median arterial pressure as the load. Our method is embedded in the software platform BioPARR-Biomechanics based Prediction of Aneurysm Rupture Risk, freely available from http://bioparr.mech.uwa.edu.au/. Experience with over 50 patient-specific stress analyses, as well as common sense, suggests that the AAA wall stress is critically dependent on the local AAA wall thickness. This thickness is currently very difficult to measure in the clinical environment. Therefore, we conducted a simulation study to elucidate the relationship between the wall thickness and the maximum principal stress. The results of the analysis of three cases presented here unequivocally demonstrate that this relationship is approximately linear, bringing us closer to being able to compute predictive stress envelopes for every patient.

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M3 - Chapter

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BT - Computational Biomechanics for Medicine

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A2 - Miller, Karol

A2 - Joldes, Grand R.

A2 - Wittek, Adam

A2 - Doyle, Barry

A2 - Nash, Martyn P.

PB - Springer International Publishing AG

CY - Switzerland

ER -

Miller K, Joldes GR, Qian J, Patel AP, Jung MS, Tavner ACR et al. Maximum principal AAA wall stress is proportional to wall thickness. In Nielsen PMF, Miller K, Joldes GR, Wittek A, Doyle B, Nash MP, editors, Computational Biomechanics for Medicine: Measurements, Models, and Predictions. Switzerland: Springer International Publishing AG. 2018. p. 43-53 https://doi.org/10.1007/978-3-319-75589-2_5