Maturation of insulin-producing cells and genetic regulation of pancreatic insulin content

Farhana Ruma

Research output: ThesisDoctoral Thesis

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Abstract

Diabetes mellitus is caused by relative or absolute deficiency of insulin-secreting ß cells. Replacement of lost or deficient ß cells would be an ideal diabetes treatment, but sufficient human ß cells are unlikely to be available to treat all diabetic patients. Therefore, an alternative method for producing ß cells is crucial. This project tested methods to generate mature insulin-­secreting cells in vitro. Transplantation of 400,000 tissue-culture-derived mature insulin-secreting cells reversed diabetes in mice. In addition, three candidate genes (Abi2, ldh1, and Map2) for regulation of pancreatic insulin content were identified using a genetically diverse mouse population, "The Gene Mine".
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Bosio, Erika, Supervisor
  • Jiang, Fang-Xu, Supervisor
  • Morahan, Grant, Supervisor
Thesis sponsors
Award date15 Nov 2019
DOIs
Publication statusUnpublished - 2019

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