Diabetes mellitus is caused by relative or absolute deficiency of insulin-secreting ß cells. Replacement of lost or deficient ß cells would be an ideal diabetes treatment, but sufficient human ß cells are unlikely to be available to treat all diabetic patients. Therefore, an alternative method for producing ß cells is crucial. This project tested methods to generate mature insulin-secreting cells in vitro. Transplantation of 400,000 tissue-culture-derived mature insulin-secreting cells reversed diabetes in mice. In addition, three candidate genes (Abi2, ldh1, and Map2) for regulation of pancreatic insulin content were identified using a genetically diverse mouse population, "The Gene Mine".
|Qualification||Doctor of Philosophy|
|Award date||15 Nov 2019|
|Publication status||Unpublished - 2019|