TY - JOUR
T1 - Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm
AU - Smallwood, Linda
AU - Warrington, Nicole
AU - Allcock, Richard
AU - Van Bockxmeer, Frank
AU - Palmer, L.J.
AU - Iacopetta, Barry
AU - Golledge, J.
AU - Norman, Paul
PY - 2009
Y1 - 2009
N2 - Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA). Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (−1360C > T, and +649C > T) in men with AAA (n = 678) and in controls (n = 659) was examined using multivariate analyses. The association with AAA expansion (n = 638) was also assessed. Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected. Conclusion: MMP2 −1360C > T and +649C > T variants are not risk factors for AAA.
AB - Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA). Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (−1360C > T, and +649C > T) in men with AAA (n = 678) and in controls (n = 659) was examined using multivariate analyses. The association with AAA expansion (n = 638) was also assessed. Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected. Conclusion: MMP2 −1360C > T and +649C > T variants are not risk factors for AAA.
U2 - 10.1016/j.ejvs.2009.04.019
DO - 10.1016/j.ejvs.2009.04.019
M3 - Article
SN - 1078-5884
VL - 38
SP - 169
EP - 171
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
IS - 2
ER -