Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm

Linda Smallwood, Nicole Warrington, Richard Allcock, Frank Van Bockxmeer, L.J. Palmer, Barry Iacopetta, J. Golledge, Paul Norman

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA). Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (−1360C > T, and +649C > T) in men with AAA (n = 678) and in controls (n = 659) was examined using multivariate analyses. The association with AAA expansion (n = 638) was also assessed. Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected. Conclusion: MMP2 −1360C > T and +649C > T variants are not risk factors for AAA.
    Original languageEnglish
    Pages (from-to)169-171
    JournalEuropean Journal of Vascular and Endovascular Surgery
    Volume38
    Issue number2
    DOIs
    Publication statusPublished - 2009

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