Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE)

Paula Rios, Helen D. Bailey, Brigitte Lacour, Dominique Valteau-Couanet, Jean Michon, Christophe Bergeron, Helene Boutroux, Anne-Sophie Defachelles, Marion Gambart, Nicolas Sirvent, Estelle Thebaud, Stephane Ducassou, Laurent Orsi, Jacqueline Clavel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Neuroblastoma (NB) is an embryonic tumor that occurs almost exclusively in infancy and early childhood. While considerable evidence suggests that it may be initiated during embryonic development, the etiology of NB is still unknown. The aim of this study was to explore whether there is an association between maternal use of household pesticides during pregnancy and the risk of NB in the offspring.

We conducted a pooled analysis of two French national-based case-control studies. The mothers of 357 NB cases and 1,783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on sociodemographic and perinatal characteristics, childhood environment, and life-style. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals.

After controlling for matching variables, study of origin, and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with NB (OR 1.5 [95% CI 1.2-1.9]). The most commonly used type of pesticides were insecticides and there was a positive association with their use alone (OR 1.4 [95% CI 1.1-1.9]) or with other pesticides (OR 2.0 [95% CI 1.1-3.4]).

Although there is the potential for recall bias due to the study design, our findings add to the evidence of an association between the household use of pesticides and NB. Until a better study design can be found, our findings add yet another reason why to advise pregnant women to limit pesticide exposure during the periconceptional period.

Original languageEnglish
Pages (from-to)1125-1132
Number of pages8
JournalCancer Causes & Control
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 2017
Externally publishedYes

Cite this

Rios, Paula ; Bailey, Helen D. ; Lacour, Brigitte ; Valteau-Couanet, Dominique ; Michon, Jean ; Bergeron, Christophe ; Boutroux, Helene ; Defachelles, Anne-Sophie ; Gambart, Marion ; Sirvent, Nicolas ; Thebaud, Estelle ; Ducassou, Stephane ; Orsi, Laurent ; Clavel, Jacqueline. / Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE). In: Cancer Causes & Control. 2017 ; Vol. 28, No. 10. pp. 1125-1132.
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title = "Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE)",
abstract = "Neuroblastoma (NB) is an embryonic tumor that occurs almost exclusively in infancy and early childhood. While considerable evidence suggests that it may be initiated during embryonic development, the etiology of NB is still unknown. The aim of this study was to explore whether there is an association between maternal use of household pesticides during pregnancy and the risk of NB in the offspring.We conducted a pooled analysis of two French national-based case-control studies. The mothers of 357 NB cases and 1,783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on sociodemographic and perinatal characteristics, childhood environment, and life-style. Unconditional logistic regression was used to estimate pooled odds ratios and 95{\%} confidence intervals.After controlling for matching variables, study of origin, and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with NB (OR 1.5 [95{\%} CI 1.2-1.9]). The most commonly used type of pesticides were insecticides and there was a positive association with their use alone (OR 1.4 [95{\%} CI 1.1-1.9]) or with other pesticides (OR 2.0 [95{\%} CI 1.1-3.4]).Although there is the potential for recall bias due to the study design, our findings add to the evidence of an association between the household use of pesticides and NB. Until a better study design can be found, our findings add yet another reason why to advise pregnant women to limit pesticide exposure during the periconceptional period.",
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Rios, P, Bailey, HD, Lacour, B, Valteau-Couanet, D, Michon, J, Bergeron, C, Boutroux, H, Defachelles, A-S, Gambart, M, Sirvent, N, Thebaud, E, Ducassou, S, Orsi, L & Clavel, J 2017, 'Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE)' Cancer Causes & Control, vol. 28, no. 10, pp. 1125-1132. https://doi.org/10.1007/s10552-017-0944-5

Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE). / Rios, Paula; Bailey, Helen D.; Lacour, Brigitte; Valteau-Couanet, Dominique; Michon, Jean; Bergeron, Christophe; Boutroux, Helene; Defachelles, Anne-Sophie; Gambart, Marion; Sirvent, Nicolas; Thebaud, Estelle; Ducassou, Stephane; Orsi, Laurent; Clavel, Jacqueline.

In: Cancer Causes & Control, Vol. 28, No. 10, 10.2017, p. 1125-1132.

Research output: Contribution to journalArticle

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T1 - Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE)

AU - Rios, Paula

AU - Bailey, Helen D.

AU - Lacour, Brigitte

AU - Valteau-Couanet, Dominique

AU - Michon, Jean

AU - Bergeron, Christophe

AU - Boutroux, Helene

AU - Defachelles, Anne-Sophie

AU - Gambart, Marion

AU - Sirvent, Nicolas

AU - Thebaud, Estelle

AU - Ducassou, Stephane

AU - Orsi, Laurent

AU - Clavel, Jacqueline

PY - 2017/10

Y1 - 2017/10

N2 - Neuroblastoma (NB) is an embryonic tumor that occurs almost exclusively in infancy and early childhood. While considerable evidence suggests that it may be initiated during embryonic development, the etiology of NB is still unknown. The aim of this study was to explore whether there is an association between maternal use of household pesticides during pregnancy and the risk of NB in the offspring.We conducted a pooled analysis of two French national-based case-control studies. The mothers of 357 NB cases and 1,783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on sociodemographic and perinatal characteristics, childhood environment, and life-style. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals.After controlling for matching variables, study of origin, and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with NB (OR 1.5 [95% CI 1.2-1.9]). The most commonly used type of pesticides were insecticides and there was a positive association with their use alone (OR 1.4 [95% CI 1.1-1.9]) or with other pesticides (OR 2.0 [95% CI 1.1-3.4]).Although there is the potential for recall bias due to the study design, our findings add to the evidence of an association between the household use of pesticides and NB. Until a better study design can be found, our findings add yet another reason why to advise pregnant women to limit pesticide exposure during the periconceptional period.

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KW - Neuroblastoma

KW - Pesticides

KW - Risk factors

KW - Childhood cancer

KW - Case-control study

KW - CORD BLOOD

KW - EXPOSURE

KW - CANCER

KW - CHILDREN

KW - TUMORS

U2 - 10.1007/s10552-017-0944-5

DO - 10.1007/s10552-017-0944-5

M3 - Article

VL - 28

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EP - 1132

JO - Cancer Causes & Control

JF - Cancer Causes & Control

SN - 0957-5243

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